{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:33:11Z","timestamp":1789147991317,"version":"build-2803163510"},"reference-count":8,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Advances in vascular reconstruction devices and coil technologies have made coil embolization a popular and effective strategy for treatment of relatively wide-neck cerebral aneurysms. However, coil protrusion occurs occasionally, and little is known about the frequency, the risk factors and the risk of thrombo-embolic complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We assessed the frequency and the risk factors for coil protrusion in 330 unruptured aneurysm embolization cases, and examined the occurrence of cerebral infarction by diffusion-weighted magnetic resonance imaging (DW-MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Forty-four instances of coil protrusion were encountered during coil embolization (13.3% of cases), but incidence was reduced to 33 (10% of cases) by balloon press or insertion of the next coil. Coil protrusion occurred more frequently during the last phase of the procedure, and both a wide neck (large fundus to neck ratio) (OR\u2009=\u20091.84, P\u2009=\u20090.03) and an inadequately stable neck frame (OR\u2009=\u20095.49, P\u2009=\u20090.0007) increased protrusion risk. Coil protrusions did not increase the incidence of high-intensity lesions (infarcts) on DW-MRI (33.3% vs 29% of cases with no coil protrusion). However, longer operation time did increase infarct risk ( P\u2009=\u20090.0003). Thus, tail or loop type coil protrusion did not increase the risk of thrombo-embolic complications, if adequate blood flow was maintained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Coil protrusion tended to occur more frequently in cases of wide-neck aneurysms with loose neck framing. Moderate and less coil protrusion carries no additional thrombo-embolic risk, if blood flow is maintained, which can be aided by additional post-operative antiplatelet therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1591019915582375","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T20:50:59Z","timestamp":1431377459000},"page":"178-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Risk factors for coil protrusion into the parent artery and associated thrombo-embolic events following unruptured cerebral aneurysm embolization"],"prefix":"10.1177","volume":"21","author":[{"given":"Hideaki","family":"Ishihara","sequence":"first","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Center, International Medical Center, Saitama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Center, International Medical Center, Saitama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Niimi","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Center, International Medical Center, Saitama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Neki","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Center, International Medical Center, Saitama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kakehi","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Center, International Medical Center, Saitama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahoko","family":"Uemiya","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Center, International Medical Center, Saitama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Kohyama","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Center, International Medical Center, Saitama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Yamane","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Center, International Medical Center, Saitama Medical University, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,11]]},"reference":[{"key":"bibr1-1591019915582375","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2572"},{"key":"bibr2-1591019915582375","doi-asserted-by":"publisher","DOI":"10.1177\/159101990601200309"},{"key":"bibr3-1591019915582375","doi-asserted-by":"publisher","DOI":"10.1177\/15910199060120S116"},{"key":"bibr4-1591019915582375","first-page":"23","volume":"40","author":"Yamao Y","year":"2012","journal-title":"No Shinkei Geka"},{"key":"bibr5-1591019915582375","first-page":"271","volume":"40","author":"Hayashi K","year":"2012","journal-title":"No Shinkei Geka"},{"key":"bibr6-1591019915582375","first-page":"127","volume":"24","author":"Soeda A","year":"2003","journal-title":"Am J Neuroradiol"},{"key":"bibr7-1591019915582375","doi-asserted-by":"publisher","DOI":"10.2165\/11599070-000000000-00000"},{"key":"bibr8-1591019915582375","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-014-2031-y"}],"container-title":["Interventional 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