{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:53:17Z","timestamp":1777729997899,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T00:00:00Z","timestamp":1460332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>The spontaneous regression of disk herniation secondary to dehydration is a much-debated topic in medicine. Some physicians wonder whether surgical removal of the extruded nucleus pulposus is really necessary when the spontaneous disappearance of a herniated lumbar disk is a well-known phenomenon. Unfortunately, without spontaneous regression, chronic pain leads to progressive disability for which surgery seems to be the only solution. In recent years, several studies have demonstrated the utility of oxygen\u2013ozone therapy in the treatment of disk herniation, resulting in disk shrinkage. This retrospective study evaluates the outcomes of a series of patients with a history of herniated disks neuroradiologically unchanged in size for over two years, treated with oxygen\u2013ozone therapy at our center over the last 15 years. We treated 96 patients, 84 (87.5%) presenting low back pain complicated or not by chronic sciatica. No drug therapy had yielded significant benefits. A number of specialists had been consulted in two or more years resulting in several neuroradiological scans prior to the decision to undertake oxygen\u2013ozone therapy. Our study documents how ozone therapy for slipped disks \u201cunchanged over time\u201d solved the problem, with disk disruption or a significant reduction in the size of the prolapsed disk material extruded into the spinal canal.<\/jats:p>","DOI":"10.1177\/1591019916637356","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T21:23:29Z","timestamp":1460409809000},"page":"466-472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Herniated disks unchanged over time: Size reduced after oxygen\u2013ozone therapy"],"prefix":"10.1177","volume":"22","author":[{"given":"Matteo","family":"Bonetti","sequence":"first","affiliation":[{"name":"Istituto Clinico Citt\u00e0 di Brescia, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Zambello","sequence":"additional","affiliation":[{"name":"Casa di Cura \u201cFondazione Borghi\u201d, Brebbia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Bologna University, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Princiotta","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,4,11]]},"reference":[{"key":"bibr1-1591019916637356","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.1.1523297"},{"key":"bibr2-1591019916637356","doi-asserted-by":"publisher","DOI":"10.1177\/197140099300600303"},{"key":"bibr3-1591019916637356","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.3.0415"},{"key":"bibr4-1591019916637356","first-page":"25","volume":"14","author":"Iliakis E","year":"2001","journal-title":"Riv 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