{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:17:22Z","timestamp":1791487042561,"version":"4.3.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T00:00:00Z","timestamp":1508716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The occurrence of thrombus migration (TM) in middle cerebral arteries (MCAs) prior to mechanical thrombectomy (MT) in patients suffering from acute ischemic strokes is a crucial aspect as TM is associated with lower rates of complete reperfusion and worse clinical outcomes. In this study, we sought to clarify whether histological thrombus composition influences TM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 64 patients with acute MCA occlusions who had undergone MT. In 11 of the cases (17.2%) we identified TM prior to the interventions. The extracted clots were collected and histologically examined. The hematoxylin and eosin-stained specimens were quantitatively analyzed in terms of the relative fractions of the main constituents (red and white blood cells and fibrin\/platelets). The histologic patterns were correlated with the occurrence of TM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients in whom TM could be observed were more often treated in a drip-and-ship fashion (90.9% vs 41.5%, p\u2009=\u20090.003). Stroke etiology did not differ between migrated and stable thrombi. A weak tendency for higher RBC and lower F\/P content could be observed in thrombi that had migrated when compared with stable thrombi (RBC: median 41% vs 37%, p\u2009=\u20090.022 and F\/P: median 54% vs 57%, p\u2009=\u20090.024). When using a cut-off of 60% RBC content for the definition of RBC-rich thrombi, a higher portion of RBC-rich thrombi could be identified in the migrated group as opposed to the stable group (36.4% vs 5.7%, p\u2009=\u20090.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preinterventional TM may be influenced by the histological thrombus composition in a way that RBC-rich thrombi are more prone to migrate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1591019917733733","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T13:39:38Z","timestamp":1508765978000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Impact of histological thrombus composition on preinterventional thrombus migration in patients with acute occlusions of the middle cerebral artery"],"prefix":"10.1177","volume":"24","author":[{"given":"Christian","family":"Maegerlein","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Berndt","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin Elizabeth","family":"Lucia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9 Universitaetsmedizin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA, USA"},{"name":"Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Poppert","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Pelisek","sequence":"additional","affiliation":[{"name":"Clinic of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Boeckh-Behrens","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kaesmacher","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"bibr1-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13287"},{"key":"bibr2-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016641965"},{"key":"bibr3-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013105"},{"key":"bibr4-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-014-0347-x"},{"key":"bibr5-1591019917733733","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4402"},{"key":"bibr6-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.605576"},{"key":"bibr7-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000230307.03438.94"},{"key":"bibr8-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1177\/1591019916686735"},{"key":"bibr9-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005149"},{"key":"bibr10-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.01.054"},{"key":"bibr11-1591019917733733","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0825"},{"key":"bibr12-1591019917733733","doi-asserted-by":"crossref","unstructured":"Gunning GM, McArdle K, Mirza M, et\u00a0al. Clot friction variation with fibrin content; implications for resistance to thrombectomy.\n                      J Neurointerv Surg\n                      . Epub ahead of print 2 January 2017. DOI: 10.1136\/neurintsurg-2016-012721.","DOI":"10.1136\/neurintsurg-2016-012721"},{"key":"bibr13-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-013-1649-5"},{"key":"bibr14-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.10.037"},{"key":"bibr15-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2013-010986"},{"key":"bibr16-1591019917733733","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-017-1614-4"},{"key":"bibr17-1591019917733733","doi-asserted-by":"crossref","unstructured":"Prothmann S, Friedrich B, Boeckh-Behrens T, et\u00a0al. Aspiration thrombectomy in clinical routine interventional stroke treatment: Is this the end of the stent retriever era?\n                      Clin Neuroradiol\n                      . 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