{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:56:55Z","timestamp":1777730215210,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pipeline embolization devices (PEDs) are used for endovascular treatment of cerebral aneurysms but can be associated with delayed ipsilateral intraparenchymal hemorrhage (DIPH). Changes in intracranial hemodynamics after PED are poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Here, we assess hemodynamic changes after PED in patients and compare these changes in patients with and without DIPH (DIPH+ and DIPH\u2013).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Records of patients with distal internal carotid artery (ICA) aneurysms treated with PED at our institution between 2012 and 2017 were retrospectively reviewed. Regions of interest were selected proximally to PED over the cavernous ICA and distally over the middle cerebral artery (MCA), and then transit times were determined using syngo iFlow software (Siemens). Ratio of MCA to ICA transit time was compared before, after treatment, and at follow-up. Ratios were also compared between DIPH+ and DIPH\u2013 subgroups. Correlations between aneurysm size, age, and ratios were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-three patients were included. The ratio of MCA to ICA transit time decreased significantly after PED deployment (1.13 vs. 1.22, p\u2009&lt;\u20090.01). The ratio in the DIPH\u2009+\u2009subgroup ( n\u2009=\u20094) was significantly lower (1.00 vs. 1.14, p\u2009=\u20090.01) and decreased significantly more (21% vs. 4.4%, p\u2009=\u20090.02) compared to the DIPH\u2013 subgroup ( n\u2009=\u200949). The ratio tended to be higher in larger aneurysms at baseline ( r\u2009=\u20090.25, p\u2009=\u20090.07) but not after PED treatment ( r\u2009=\u20090.11, p\u2009=\u20090.15). Age did not correlate with ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ratio of MCA to ICA transit time decreases following PED treatment and decreases more in patients with DIPH. These contrast transit time changes can be detected in real time immediately after PED deployment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1591019917747248","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T03:52:44Z","timestamp":1513137164000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Intracranial contrast transit times on digital subtraction angiography decrease more in patients with delayed intraparenchymal hemorrhage after Pipeline"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-7814","authenticated-orcid":false,"given":"Denise","family":"Brunozzi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia F","family":"Shakur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fady T","family":"Charbel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alaraj","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Chicago, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"bibr1-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.678151"},{"key":"bibr2-1591019917747248","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4443"},{"key":"bibr3-1591019917747248","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4111"},{"key":"bibr4-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2014.06.021"},{"key":"bibr5-1591019917747248","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3065"},{"key":"bibr6-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-013-1302-2"},{"key":"bibr7-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-011-0948-x"},{"key":"bibr8-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2011-010129"},{"key":"bibr9-1591019917747248","doi-asserted-by":"publisher","DOI":"10.3171\/2013.11.JNS131599"},{"key":"bibr10-1591019917747248","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3621"},{"key":"bibr11-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010479.rep"},{"key":"bibr12-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02650.x"},{"key":"bibr13-1591019917747248","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.5.1233"},{"key":"bibr14-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1177\/1591019916668842"},{"key":"bibr15-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1177\/1591019916685892"},{"key":"bibr16-1591019917747248","doi-asserted-by":"crossref","unstructured":"Brunozzi D, Shakur SF, Hussein AE, et\u00a0al. Middle cerebral artery flow velocity increases more in patients with delayed intraparenchymal hemorrhage after Pipeline.\n                      J Neurointerv Surg.\n                      Epub ahead of print 2 May 2017. DOI: 10.1136\/neurintsurg-2017-013042.","DOI":"10.1136\/neurintsurg-2017-013042"},{"key":"bibr17-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012730"},{"key":"bibr18-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.203"},{"key":"bibr19-1591019917747248","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2020"},{"key":"bibr20-1591019917747248","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3049"},{"key":"bibr21-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1559"},{"key":"bibr22-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910230106"},{"key":"bibr23-1591019917747248","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(00)00157-0"}],"container-title":["Interventional Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1591019917747248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1591019917747248","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1591019917747248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:57:50Z","timestamp":1777460270000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1591019917747248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1177\/1591019917747248"],"URL":"https:\/\/doi.org\/10.1177\/1591019917747248","relation":{},"ISSN":["1591-0199","2385-2011"],"issn-type":[{"value":"1591-0199","type":"print"},{"value":"2385-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,12]]}}}