{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:11:45Z","timestamp":1789834305057,"version":"4.0.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early anatomists suspected that the radiculomedullary veins draining the spinal cord had valves preventing their retrograde filling with anatomical casting material. Modern investigations have discarded the presence of true valves and introduced instead the notion of a pseudo-valvular configuration for which the term antireflux mechanism was coined in the 1970s. The angiographic anatomy of the antireflux mechanism has not been well documented so far.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This article discusses anatomical and clinical features of the antireflux mechanism with a series of 12 angiographic observations documenting the antireflux mechanism under normal and pathological circumstances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The antireflux mechanism divides radiculomedullary veins into intradural and extradural segments. While the structure of the antireflux mechanism is not yet fully clarified, it includes at least a tight narrowing of the radiculomedullary vein at its point of passage through the thecal sac, which is angiographically detectable and likely protects the intradural venous system from transient or persistent surges in venous pressure (e.g. sneezing, pregnancy). This tight narrowing of the antireflux mechanism likely also represents an obstacle to normal anterograde flow, potentially leading to venous stagnation and thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The antireflux mechanism includes at least a tight narrowing of the radiculomedullary vein, which likely influences the development and clinical expression of low-flow spinal arteriovenous fistulas and might impact the spinal venous drainage even in the absence of arteriovenous shunts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1591019920941309","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T01:56:41Z","timestamp":1594778201000},"page":"691-702","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The antireflux mechanism \u2013 Angiographic anatomy and clinical implications"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-3273","authenticated-orcid":false,"given":"Philippe","family":"Gailloud","sequence":"first","affiliation":[{"name":"Division of Interventional Neuroradiology, The Johns Hopkins Hospital, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"bibr1-1591019920941309","volume-title":"Essai sur les veines du rachis","author":"Breschet G.","year":"1819"},{"key":"bibr2-1591019920941309","volume-title":"Die Venensysteme der menschlichen Wirbels\u00e4ule. Morphologie und funktionelle Bedeutung","author":"Clemens H.","year":"1961"},{"key":"bibr3-1591019920941309","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.20.9.860"},{"key":"bibr4-1591019920941309","volume-title":"The arteries and veins of the human spinal cord from birth","author":"Dommisse G.","year":"1975","edition":"1"},{"key":"bibr5-1591019920941309","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-3668-3"},{"key":"bibr6-1591019920941309","first-page":"3","volume":"12","author":"Tadi\u00e9 M","year":"1985","journal-title":"J Neuroradiol"},{"key":"bibr7-1591019920941309","first-page":"28","volume":"25","author":"Tadi\u00e9 M","year":"1979","journal-title":"Neurochirurgie"},{"key":"bibr8-1591019920941309","first-page":"550","volume":"162","author":"Tadi\u00e9 M","year":"1978","journal-title":"Bull Acad National M\u00e9d"},{"key":"bibr9-1591019920941309","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3111"},{"key":"bibr10-1591019920941309","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-014-1404-5"},{"key":"bibr11-1591019920941309","doi-asserted-by":"publisher","DOI":"10.3171\/2014.11.SPINE14786"},{"key":"bibr12-1591019920941309","unstructured":"Oswald K.\n                      Untersuchungen \u00fcber das Vorkommen von Sperrmechanismen in den Venae radiculares des Menschen\n                      . 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