{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:58:28Z","timestamp":1783353508597,"version":"3.54.6"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004826","name":"National Natural Science Foundation of Beijing","doi-asserted-by":"crossref","award":["7212007"],"award-info":[{"award-number":["7212007"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Distal cerebral circulation aneurysms (DCCAs) remain treatment challenges for neurointervention. The off-label use of the pipeline embolization device (PED) for these aneurysms remains controversial. This study aimed to evaluate the safety and efficacy of PED for DCCAs in a multicenter cohort of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between March 2016 and June 2021, we retrospectively analyzed the neurointerventional data on the clinical and radiological records of all patients undergoing PED treatment of DCCAs at three medical centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 53 consecutive patients with 53 DCCAs were treated with PED. The mean aneurysm size was 12.3\u2009\u00b1\u20095.7\u2005mm. In total, 75.4% (40\/53) were fusiform and 24.5% (13\/53) were saccular. Of these, 17.0% (9\/53) were recurrent aneurysms that were previously treated with endovascular or microsurgical approaches. The technical success rate was 100%, among which 81.1% (43\/53) procedures were completed with a single PED, and the rest (10\/53, 18.8%) required telescoping with two devices. Angiographic follow-up data were available for 51 patients, with a median follow-up time of 12 months. At the latest follow-up, 46\/51 (90.2%) aneurysms showed complete obliteration, and 4\/51 (7.8%) showed reduced filling. Periprocedural complications such as hemorrhage were observed in two patients with MCA aneurysms (3.8%, 2\/53), and ischemic events occurred in six patients (11.3%, 6\/53). The overall mortality and morbidity rates were 7% (4\/53).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PED is a viable option for treating DCCAs, especially for recurrent aneurysms. Coverage of bifurcation branches and perforator may increase the risk of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199211063703","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T09:38:05Z","timestamp":1639647485000},"page":"708-718","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Pipeline for the treatment of distal cerebral circulation aneurysms: A multicenter study focusing on periprocedural Complications"],"prefix":"10.1177","volume":"28","author":[{"given":"Chao","family":"Ma","sequence":"first","affiliation":[{"name":"Interventional Neuroradiology Center, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Interventional Neuroradiology Center, Beijing Neurosurgical 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