{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:00:30Z","timestamp":1791378030030,"version":"4.3.2"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While many of the causes of pulsatile tinnitus (PT) are treatable with endovascular approaches, the risks of treatment must be balanced with the risks of the underlying cause and the psychological impact of symptoms on patients. While many physicians have anecdotal experience, the comorbid relationship of depression and anxiety with PT is unknown. The objectives of this study are to quantify the prevalence of depression and anxiety, and, to identify the demographic risk factors for impactful depression and anxiety in patients with PT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects recruited from online PT groups filled out secure online questionnaires that included demographic questions, validated Tinnitus Functional Index (TFI) as well as PHQ-9 and GAD-7 questionnaires to assess the prevalence of concurrent depression and anxiety, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sample included 515 surveys (84% female, 65% unemployed, mean(sd) age\u2009=\u200946.4 years (14.2)). Median symptom duration was 1.9 years. Data showed 46% and 37% of patients with moderate to severe depression and anxiety, respectively. Higher TFI scores were associated with moderate to severe depression (OR 1.07; 95% CI 1.06\u20131.09, p\u2009&lt;\u20090.001) and anxiety (OR 1.05, 95% CI 1.04\u20131.06, p\u2009&lt;\u20090.001), with TFI subscores also independently being associated in a univariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of moderate to severe depression and anxiety in the PT population, which was previously unknown, is estimated in our study to be 46% and 37%, respectively. Significant association of TFI score with increased depression and anxiety scales adds further evidence of the impact of PT on the psychological health of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199231168751","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T01:26:57Z","timestamp":1681781217000},"page":"381-385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["More than just noise: Association of pulsatile tinnitus with anxiety, depression, and reduction of quality of life"],"prefix":"10.1177","volume":"31","author":[{"given":"Matthew","family":"Amans","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California at San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-9503","authenticated-orcid":false,"given":"Raghav","family":"Mattay","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California at San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy K","family":"Hills","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA"},{"name":"Department of Neurology, McLaren Northern Michigan Hospital, Petoskey, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California at San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California at San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2019-5461","authenticated-orcid":false,"given":"Kazim","family":"Narsinh","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California at San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Meisel","sequence":"additional","affiliation":[{"name":"Department of Neurology, McLaren Northern Michigan Hospital, Petoskey, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2008.08.014"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182a4756c"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.4470"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019259"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-018015"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819835178"},{"key":"e_1_3_2_8_2","unstructured":"Major Depression. National Institute of Mental Health (NIMH). https:\/\/www.nimh.nih.gov\/health\/statistics\/major-depression (accessed 10 January 2023)."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26107"},{"key":"e_1_3_2_10_2","unstructured":"Any Anxiety Disorder. National Institute of Mental Health (NIMH). https:\/\/www.nimh.nih.gov\/health\/statistics\/any-anxiety-disorder (accessed 10 January 2023)."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.621145"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811403381"},{"key":"e_1_3_2_13_2","article-title":"Emergence of venous stenosis as the dominant cause of pulsatile tinnitus","volume":"2","author":"Raz E","year":"2022","unstructured":"Raz E, Nossek E, Jethanamest D, et al. Emergence of venous stenosis as the dominant cause of pulsatile tinnitus. Stroke Vasc Interv Neurol 2022; 2: e000154. .","journal-title":"Stroke Vasc Interv Neurol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000165928.19135.35"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.00269.x"}],"container-title":["Interventional Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199231168751","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15910199231168751","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199231168751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:56:29Z","timestamp":1777460189000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15910199231168751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1177\/15910199231168751"],"URL":"https:\/\/doi.org\/10.1177\/15910199231168751","relation":{},"ISSN":["1591-0199","2385-2011"],"issn-type":[{"value":"1591-0199","type":"print"},{"value":"2385-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]}}}