{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:50:58Z","timestamp":1777729858458,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Large vessel occlusion (LVO) prediction scales are used to triage prehospital suspected stroke patients with a high probability of LVO stroke to endovascular therapy centers. The sensitivities of these scales in the 6-to-24-h time window are unknown. Higher scale score thresholds are typically less sensitive and more specific. Knowing the highest scale score thresholds that remain sensitive could inform threshold selection for clinical use. Sensitivities may also vary between left and right-sided LVOs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>LVO prediction scale scores were retrospectively calculated using the National Institutes of Health Stroke Scale (NIHSS) scores of patients enrolled in the DAWN Trial. All patients had last known well times between 6 and 24\u2005h, NIHSS scores\u2009\u2265\u200910, intracranial internal carotid artery or proximal middle cerebral artery occlusions, and mismatches between their clinical severities and infarct core volumes. Scale thresholds with sensitivities\u2009\u2265\u200985% were identified, along with scores\u2009\u2265\u20095% more sensitive for left or right-sided LVOs. Specificities could not be calculated because all patients had LVOs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 201 out of 206 patients had the required NIHSS subitem scores. CPSS\u2009=\u20093, C-STAT\u2009\u2265\u20092, FAST-ED\u2009\u2265\u20094, G-FAST\u2009\u2265\u20093, RACE\u2009\u2265\u20095, and SAVE\u2009\u2265\u20093 were the highest thresholds that were still 85% sensitive for DAWN Trial LVO stroke patients. RACE\u2009\u2265\u20095 was the only typically used score threshold more sensitive for right-sided LVOs, though similar small differences were seen for other scales at higher thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings likely represent the maximum sensitivities of the LVO prediction scales tested for ideal thrombectomy candidates in the 6-to-24-h time window because NIHSS scores were documented in hospitals during a clinical trial rather than in the prehospital setting. Patients with NIHSS scores\u2009&lt;\u200910 or more distal LVOs would lower sensitivities further. Selecting even higher scale thresholds for LVO triage would lead to many missed LVO strokes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199231203266","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T01:13:02Z","timestamp":1698887582000},"page":"795-803","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Large vessel occlusion prediction scale thresholds that are sensitive for DAWN Trial patients"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-9878","authenticated-orcid":false,"given":"Kevin J","family":"Keenan","sequence":"first","affiliation":[{"name":"University of California, Davis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wade S","family":"Smith","sequence":"additional","affiliation":[{"name":"University of California, San Francisco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh P","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo C","family":"Haussen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Radiology, Emory University School of Medicine at Grady Memorial Hospital, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald F","family":"Budzik","sequence":"additional","affiliation":[{"name":"OhioHealth"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Bonaf\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Hospital of Montpellier, Hop Gui de Chauliac, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parita","family":"Bhuva","sequence":"additional","affiliation":[{"name":"Texas Stroke Institute at HCA North Texas, Plano, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dileep R","family":"Yavagal","sequence":"additional","affiliation":[{"name":"University of Miami School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Rib\u00f2","sequence":"additional","affiliation":[{"name":"Vall d'Hebron University Hospital, Vall d'Hebron Research Institute, Barcelona, Spain"},{"name":"Department of Neurology, Vall d'Hebron University Hospital, Stroke Unit, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4287-2627","authenticated-orcid":false,"given":"Christophe","family":"Cognard","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Hospital Purpan, Toulouse, Midi-Pyr\u00e9n\u00e9es, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A","family":"Hanel","sequence":"additional","affiliation":[{"name":"Baptist Medical Center Jacksonville\/Lyerly Neurosurgery, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-7616","authenticated-orcid":false,"given":"Ameer E","family":"Hassan","sequence":"additional","affiliation":[{"name":"Valley Baptist Medical Center - Harlingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy A","family":"Sila","sequence":"additional","affiliation":[{"name":"University Hospitals Cleveland Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L","family":"Saver","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-8736","authenticated-orcid":false,"given":"David S","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudor G","family":"Jovin","sequence":"additional","affiliation":[{"name":"Cooper Hospital University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul G","family":"Nogueira","sequence":"additional","affiliation":[{"name":"UPMC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033228"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003071"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30439-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873211015861"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4418"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/10903127.2017.1387629"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/10903127.2016.1274349"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.013301"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014431"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014482"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012131"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"50","author":"Powers WJ","year":"2019","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke. 2019; 50: e344\u2013e418.","journal-title":"Stroke"},{"key":"e_1_3_3_15_2","unstructured":"Kohn M. Confidence interval for a proportion | Sample Size Calculators [Internet]. Cited 2022 Apr 28. Available from: https:\/\/sample-size.net\/confidence-interval-proportion\/."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014519"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4425"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.636928"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.023811"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.028956"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027756"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511759512.006"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.039825"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-021-00937-x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99828-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-01144-6"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-019-00845-x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031225"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030150"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013690"}],"container-title":["Interventional Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199231203266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15910199231203266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199231203266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:56:39Z","timestamp":1777460199000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15910199231203266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/15910199231203266"],"URL":"https:\/\/doi.org\/10.1177\/15910199231203266","relation":{},"ISSN":["1591-0199","2385-2011"],"issn-type":[{"value":"1591-0199","type":"print"},{"value":"2385-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]}}}