{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:42:36Z","timestamp":1786167756841,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Posterior cerebral arteries with acute ischemic strokes (PCA-AISs) comprise around 2% of all acute ischemic strokes and may result in significant long-term deficits. Current guidance regarding endovascular thrombectomy (EVT) for PCA-AIS is insufficient as no published randomized trials exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An analysis of the National Inpatient Sample database compared medical management versus EVT for PCA-AIS. Propensity score matching was applied to adjust for nonrandomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 19,655 patients. Before matching, the EVT cohort had significantly higher National Institutes of Health Stroke Scale (NIHSS) (10.21 vs. 4.67,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), had lower rates of favorable functional outcomes, functional independence, and higher rates of intracranial hemorrhage (ICH) and inpatient mortality. After matching, no differences in functional outcomes were identified, but revealed a higher proportion of ICH in the EVT group (17.45% vs. 8.98%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, NIHSS subgroup analysis identified improved functional outcomes associated with the EVT group who presented with an NIHSS between 10 and 19 both in terms of rates of favorable functional outcomes (35.56% vs. 12.09%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and rates of functional independence (26.67% vs. 9.34%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01). On further investigation, the clinical benefit, in the NIHSS 10-19 subgroup, was driven by patients receiving EVT in combination with intravenous thrombolysis (IVT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This analysis shows that current national practices utilize EVT for more severe PCA strokes. Clinical benefit was only detected in patients with moderate stroke severity (NIHSS 10-19) who were treated with combined EVT and IVT. Further work is needed to investigate the features of PCA-AIS that might benefit from EVT the most.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199231223535","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T03:42:37Z","timestamp":1705981357000},"page":"1210-1218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Endovascular thrombectomy for posterior cerebral artery strokes in the national inpatient sample (EaT PeCANpIeS) study"],"prefix":"10.1177","volume":"32","author":[{"given":"Aaron","family":"Brake","sequence":"first","affiliation":[{"name":"The University of Kansas School of Medicine"},{"name":"Department of Neurology"},{"name":"University of Iowa Hospitals and Clinics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0728-2242","authenticated-orcid":false,"given":"Lane","family":"Fry","sequence":"additional","affiliation":[{"name":"The University of Kansas School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Heskett","sequence":"additional","affiliation":[{"name":"The University of Kansas School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Rahman","family":"Alkiswani","sequence":"additional","affiliation":[{"name":"The University of Kansas School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"LeBeau","sequence":"additional","affiliation":[{"name":"The University of Kansas School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"De Stefano","sequence":"additional","affiliation":[{"name":"University of Kansas Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lei","sequence":"additional","affiliation":[{"name":"The University of Kansas School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Le","sequence":"additional","affiliation":[{"name":"The University of Kansas School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3785-1442","authenticated-orcid":false,"given":"Adam G","family":"Rouse","sequence":"additional","affiliation":[{"name":"University of Kansas Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9421-5632","authenticated-orcid":false,"given":"Jeremy","family":"Peterson","sequence":"additional","affiliation":[{"name":"University of Kansas Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ebersole","sequence":"additional","affiliation":[{"name":"University of Kansas Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029949"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.028956"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15410"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 Update to the 2018 guidelines for the early management of acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"50","author":"Powers WJ","year":"2019","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, , et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 Update to the 2018 guidelines for the early management of acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association. 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