{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T02:42:39Z","timestamp":1786156959389,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The flow re-direction endoluminal device (FRED) is a safe and effective treatment option for intracranial aneurysms. The novel FRED X features an antithrombotic surface coating (\u201cX Technology\u201d) on an otherwise unmodified stent design. This two-center study evaluates the clinical safety and efficacy of FRED X and compares it to the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients treated between 2020 and 2023 were retrospectively reviewed for aneurysm characteristics, procedural details and complications, and angiographic outcomes. A mini-review of the literature for FRED X clinical trials was performed and results were pooled using a random effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-four patients (mean age 56 years) were treated for 34 aneurysms. The mean aneurysm size was 7.7\u2009\u00b1\u20095.0\u2005mm, 7 (21%) were ruptured, 6 (18%) were recurrent after previous treatment, 11 (32.3%) were located in the posterior circulation, and 4 (12.5%) had non-saccular morphology. All procedures were technically successful and no balloon angioplasty was required. There was 1 (2.9%) symptomatic complication (a transient ischemic attack) and no procedural morbidity or mortality. Technical asymptomatic events included 1 procedural stent occlusion that was reopened with thrombectomy and 3 cases of vasospasm. Complete and adequate occlusion rates were 68% (19\/28) and 89% (25\/28) at a mean follow-up time of 6 months, respectively. The results of this study are comparable to previous FRED X studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results demonstrate a high feasibility and procedural safety of the FRED X with adequate mid-term occlusion rates. Long-term and comparative studies are needed to evaluate the full potential of the FRED X.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199241246018","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T04:22:47Z","timestamp":1713846167000},"page":"1395-1403","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["FRED X flow diverter for the treatment of intracranial aneurysms: Two-center experience and mini-review of the literature"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-7611","authenticated-orcid":false,"given":"Lukas","family":"Goertz","sequence":"first","affiliation":[{"name":"University of Cologne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Styczen","sequence":"additional","affiliation":[{"name":"University Hospital Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Siebert","sequence":"additional","affiliation":[{"name":"University Hospital Berlin (Charit\u00e9)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"University Hospital Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schlamann","sequence":"additional","affiliation":[{"name":"University of Cologne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Forsting","sequence":"additional","affiliation":[{"name":"University Hospital Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Bohner","sequence":"additional","affiliation":[{"name":"University Hospital Berlin (Charit\u00e9)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9262-7289","authenticated-orcid":false,"given":"Cornelius","family":"Deuschl","sequence":"additional","affiliation":[{"name":"University Hospital Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kabbasch","sequence":"additional","affiliation":[{"name":"University of Cologne"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4111"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.678151"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4329"},{"key":"e_1_3_2_5_2","first-page":"159101992312075","article-title":"Flow diverter surface modifications for aneurysm treatment: a review of the mechanisms and data behind existing technologies","author":"White TG","year":"2023","unstructured":"White TG, Santhumayor BA, Turpin J, et al. Flow diverter surface modifications for aneurysm treatment: a review of the mechanisms and data behind existing technologies. Interv Neuroradiol 2023: 15910199231207550.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199211027991"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7834"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-021103"},{"key":"e_1_3_2_9_2","first-page":"1","article-title":"First United States multicenter experience with the new-generation FRED X surface-modified flow diversion stent: feasibility, safety, and short-term efficacy","volume":"1","author":"Abbas R","year":"2023","unstructured":"Abbas R, Lan M, El Naamani K, et al. First United States multicenter experience with the new-generation FRED X surface-modified flow diversion stent: feasibility, safety, and short-term efficacy. J Neurosurg 2023; 1: 1\u201310.","journal-title":"J Neurosurg"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019248"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030566"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013559"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/2019.1.JNS183005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3171\/2022.7.JNS221371"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-017469"},{"key":"e_1_3_2_16_2","first-page":"159101992312209","article-title":"Multicenter study of the safety and effectiveness of intracranial aneurysm treatment with the p64MW-HPC flow modulation device","author":"Ernst M","year":"2023","unstructured":"Ernst M, Jamous A, Bartl M, et al. Multicenter study of the safety and effectiveness of intracranial aneurysm treatment with the p64MW-HPC flow modulation device. Interv Neuroradiol 2023: 15910199231220964.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-021182"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025407"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-020250"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000446503"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014261"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2020.11.006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3623"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-023-01346-3"}],"container-title":["Interventional Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199241246018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15910199241246018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199241246018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T01:48:35Z","timestamp":1786153715000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15910199241246018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/15910199241246018"],"URL":"https:\/\/doi.org\/10.1177\/15910199241246018","relation":{},"ISSN":["1591-0199","2385-2011"],"issn-type":[{"value":"1591-0199","type":"print"},{"value":"2385-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}