{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T05:42:38Z","timestamp":1786167758060,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>There are few studies on flow diverters with diameters &gt;5 mm. We present our preliminary experience with the 5.5\u20138 mm Derivo Embolization Device (DED) implants for the treatment of cerebral aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A consecutive series of 26 patients (median age: 60 years) treated for 32 aneurysms in 26 procedures was retrospectively analyzed for procedural characteristics, complications, and mid-term angiographic results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median aneurysm size was 10.5 mm, 2 of 30 (6%) aneurysms were ruptured and 9 (28%) had a fusiform or dissecting morphology. DED implantation was performed in the internal carotid artery in 18 of 26 (69%) procedures and in the vertebrobasilar artery in 8 (31%). Device deployment failed in 1 (4%) procedure. The 7 and 8 mm implants were successfully deployed in 5 cases. Additional balloon angioplasty or stent implantation was performed in 3 (12%) cases to improve wall apposition. Complications included 1 (4%) major stroke and 2 (8%) minor strokes. Angiographic follow up at a mean of 6 months showed complete occlusion in 8 of30 (27%) aneurysms and favorable occlusion in 14 (47%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of large diameter DEDs was safe and feasible. The mid-term occlusion rates are acceptable considering the complex subset of aneurysms studied. Further studies are warranted to define the indications for large-diameter DEDs and to evaluate their long-term efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199241248479","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:55:12Z","timestamp":1714956912000},"page":"1455-1463","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of intracranial aneurysms with large-diameter (\u22655.5 mm) Derivo Embolization Devices, with particular focus on 7 and 8 mm diameter devices"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-7611","authenticated-orcid":false,"given":"Lukas","family":"Goertz","sequence":"first","affiliation":[{"name":"Faculty of Medicine and University Hospital, Department of Radiology and Neuroradiology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-7453","authenticated-orcid":false,"given":"David","family":"Zopfs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital, Department of Radiology and Neuroradiology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kottlors","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital, Department of Radiology and Neuroradiology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenhard","family":"Pennig","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital, Department of Radiology and Neuroradiology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schob","sequence":"additional","affiliation":[{"name":"Department of Radiology and Neuroradiology, University Hospital Halle, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schlamann","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital, Department of Radiology and Neuroradiology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kabbasch","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital, Department of Radiology and Neuroradiology, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011708"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001785"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.3.FOCUS1748"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000392"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy092"},{"key":"e_1_3_2_7_2","first-page":"159101992312075","article-title":"Flow diverter surface modifications for aneurysm treatment: a review of the mechanisms and data behind existing technologies","author":"White TG","year":"2023","unstructured":"White TG, Santhumayor BA, Turpin J, et al. Flow diverter surface modifications for aneurysm treatment: a review of the mechanisms and data behind existing technologies. Interv Neuroradiol 2023: 15910199231207550.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-021-03007-9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4807"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-013963"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025407"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3080"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.3.FOCUS16450"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-021-01086-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019220"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016303"},{"key":"e_1_3_2_17_2","first-page":"159101992311935","article-title":"First clinical experience with the Derivo 2heal Embolization Device for the treatment of intracranial aneurysms","author":"Goertz L","year":"2023","unstructured":"Goertz L, Zopfs D, Sch\u00f6nfeld M, et al. First clinical experience with the Derivo 2heal Embolization Device for the treatment of intracranial aneurysms. Interv Neuroradiol 2023: 15910199231193577.","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS14411"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-021120"}],"container-title":["Interventional Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199241248479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15910199241248479","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199241248479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:48:56Z","timestamp":1786164536000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15910199241248479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,5]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/15910199241248479"],"URL":"https:\/\/doi.org\/10.1177\/15910199241248479","relation":{},"ISSN":["1591-0199","2385-2011"],"issn-type":[{"value":"1591-0199","type":"print"},{"value":"2385-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,5]]}}}