{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:26:05Z","timestamp":1791411965560,"version":"4.3.3"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Major Chronic Disease Program of the Ministry of Science and Technology of China","award":["No. 2018YFC1312301"],"award-info":[{"award-number":["No. 2018YFC1312301"]}]},{"name":"the General Program of the National Natural Science Foundation of China","award":["No. 82071442"],"award-info":[{"award-number":["No. 82071442"]}]},{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","award":["JLSWSRCZX2021-004"],"award-info":[{"award-number":["JLSWSRCZX2021-004"]}],"id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between von Willebrand factor (vWF) and neutrophil extracellular traps (NETs) in thrombus with clinical severity and peripheral blood immunocytes\u2019 indicators in patients with early-stage acute ischemic stroke (AIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted using the clinical data of 66 patients with AIS who underwent endovascular mechanical thrombectomy and had their thrombus samples collected. The concentrations of vWF and NETs in the thrombus samples were quantitatively assessed. Peripheral blood samples taken in the early stages of the disease were analyzed for total white blood cell counts (WBC), ratios of neutrophils (NEU%), lymphocytes (LYM%), eosinophils (EOS%), and monocytes (MONO%). The severity of clinical symptoms in these patients was evaluated using the modified Rankin Scale (mRS), Essen Stroke Risk Score (ESRS), Barthel Index (BI), and National Institute of Health Stroke Scale (NIHSS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher vWF levels in thrombus were associated with lower NIHSS scores, while higher NETs levels were associated with higher initial NIHSS scores. In the early stages of AIS, WBC count and vWF levels were negatively correlated, as well as NEU%. LYM% was positively correlated with vWF level; however, it was negatively correlated with NETs. EOS% was positively correlated with vWF levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the early stages of AIS, a higher peripheral WBC count and NEU%, combined with decreased EOS% and LYM%, were significantly correlated with a lower vWF level in the thrombus, potentially indicating more severe symptoms. Consequently, the timely administration of vWF-targeted medications is recommended for such patients. Reduced LYM% is indicative of elevated NETs levels and correlated with more severe clinical symptoms. Therefore, the prompt initiation of NETs-targeted medication is warranted for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199241258374","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T03:19:31Z","timestamp":1716952771000},"page":"1510-1517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Relationship between thrombus vWF and NETs with clinical severity and peripheral blood immunocytes\u2019 indicators in patients with acute ischemic stroke"],"prefix":"10.1177","volume":"32","author":[{"given":"Shi","family":"Lin","sequence":"first","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chunxiao","sequence":"additional","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-4653","authenticated-orcid":false,"given":"Sun","family":"Li","sequence":"additional","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Guimei","sequence":"additional","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Yaru","sequence":"additional","affiliation":[{"name":"Department of Neurology and National Center for Neurological Diseases, Huashan Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhai","family":"Weijie","sequence":"additional","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yiming","sequence":"additional","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Ruolin","sequence":"additional","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lingjie","sequence":"additional","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Yan","sequence":"additional","affiliation":[{"name":"Cognitive Center, Department of Neurology, The First Hospital of Jilin University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00228-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012801"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034289"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032810"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200303000-00008"},{"key":"e_1_3_3_7_2","first-page":"12","article-title":"Association of genetic and allelic variants of von Willebrand factor (VWF), glutathione S-transferase and tumor necrosis factor alpha with ischemic stroke susceptibility and progression in the Saudi population","volume":"13","author":"Jalal MM","year":"2023","unstructured":"Jalal MM, Mir R, Hamadi A, et al. 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