{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:01:03Z","timestamp":1790694063174,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R5R44NS095573-04"],"award-info":[{"award-number":["R5R44NS095573-04"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Therapeutic hypothermia has shown potential in cardiac intervention for years; however, its adoption into the neurovascular space has been limited. Studies have pointed to slow cooling and limited depth of hypothermia yielding negative outcomes. Here we present an insulated catheter that allows for consistent infusion of chilled saline directly to the brain. Direct delivery of cold saline allows a faster depth of hypothermia, which could have a benefit to the growth of ischemic lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten canines were randomized to either receive selective brain cooling or no additional therapy. Eight animals were successfully enrolled (n\u2009=\u20094 per group). Each animal underwent a temporary middle cerebral artery occlusion (MCAO) for a total of 45\u2005min. Five minutes prior to flow restoration, chilled saline was injected through the ipsilateral internal carotid artery using an insulated catheter to ensure delivery temperature. The treatment continued for 20\u2005min, after which the animal was transferred to an MRI scanner for imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 8 animals that were successfully enrolled in the study, 3 were able to survive to the 30-day endpoint with no differences between the cooled and control animals. There was no difference in the initial mean infarct size between the groups; however, animals that did not receive cooling had infarcts continuing to progress more rapidly after the MCAO was removed (13.8% vs 161.3%, p\u2009=\u20090.016, cooled vs control).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Selective hypothermia was able to reduce the post-MCAO infarct progression in a canine model of temporary MCAO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199241266010","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T19:01:21Z","timestamp":1721761281000},"page":"2116-2123","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Selective brain cooling with a novel catheter reduces infarct growth after recanalization in a canine large vessel occlusion model"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-9110","authenticated-orcid":false,"given":"Robert M","family":"King","sequence":"first","affiliation":[{"name":"University of Massachusetts Chan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-3192","authenticated-orcid":false,"given":"Vania","family":"Anagnostakou","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Salman","family":"Shazeeb","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School"},{"name":"University of Massachusetts Chan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Hornibrook","sequence":"additional","affiliation":[{"name":"FocalCool, LLC, Sewell, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Mitchell","sequence":"additional","affiliation":[{"name":"FocalCool, LLC, Sewell, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Epshtein","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Raskett","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Henninger","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit S","family":"Puri","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Merrill","sequence":"additional","affiliation":[{"name":"FocalCool, LLC, Sewell, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8034-2785","authenticated-orcid":false,"given":"Matthew J","family":"Gounis","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022737"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001232"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-020-02586-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020315"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026448"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029830"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199221095798"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199211073019"},{"key":"e_1_3_2_10_2","article-title":"Repeated mechanical thrombectomy for recurrent large vessel occlusion: a systematic review and meta-analysis","volume":"0","author":"Elfil M","year":"2022","unstructured":"Elfil M, Bahbah EI, Bayoumi A, et al. 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