{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:01:31Z","timestamp":1790694091369,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute ischemic stroke (AIS) due to intracranial atherosclerotic disease (ICAD) carries a high risk of recurrence despite aggressive medical management. The aim of our study is to present our initial experience with the Onyx Frontier\u2122 balloon-mounted drug-eluting stent (Medtronic, Santa Rosa, CA) for AIS due to ICAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective cohort study describing the technical feasibility, safety, and performance of using the Onyx Frontier\u2122 balloon-mounted drug-eluting stent in patients with acute intracranial vessel occlusion due to ICAD across three comprehensive stroke centers in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 23 patients in our study (mean age 67.3 [10.7]; females: n\u2009=\u200913\/23, 56.5%). Most patients were Black (n\u2009=\u200914\/23, 60.9%). The most common site of vessel occlusion was the M1 branch of the middle cerebral artery (MCA) (n\u2009=\u200914\/23, 60.9%), followed by the vertebrobasilar system (n\u2009=\u20095\/23, 21.7%), and the internal carotid artery (n\u2009=\u20093\/23, 13.0%). Treatment with the Onyx Frontier\u2122 stent was associated with a final mTICI score \u22652b for 100% of patients, with no vessel perforations or distal embolization. None of the patients had any restenosis or re-treatment over a median follow-up of 3.5 months (interquartile range [IQR] 7.8). All cases required a single stent except for one, where two were deployed. Transfemoral access was used in most cases (n\u2009=\u200918\/23, 78.3%), with one in-hospital death due to access site complication (n\u2009=\u20091\/23, 4.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the largest multicenter cohort study demonstrating the feasibility and safety of using the Onyx Frontier\u2122 balloon-mounted zotarolimus-eluting stent to treat symptomatic AIS due to ICAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199241286922","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T04:05:18Z","timestamp":1729483518000},"page":"2505-2514","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of Onyx Frontier\n                    <sup>\u2122<\/sup>\n                    for intracranial stenting in stroke patients: A multicenter retrospective study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7531-8069","authenticated-orcid":false,"given":"Ahmad","family":"Chahine","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2131-3711","authenticated-orcid":false,"given":"Rami Z.","family":"Morsi","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonam","family":"Thind","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-6824","authenticated-orcid":false,"given":"Omar","family":"Kass-Hout","sequence":"additional","affiliation":[{"name":"Department of Neurology, Access TeleCare, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Becske","sequence":"additional","affiliation":[{"name":"UNC REX Healthcare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Khaldi","sequence":"additional","affiliation":[{"name":"WellStar Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2021-086X","authenticated-orcid":false,"given":"Lina","family":"Karar","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archit","family":"Baskaran","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Carri\u00f3n-Penagos","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin A.","family":"Kothari","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okker","family":"Verhagen Metman","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehad","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atman P.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Chicago, Chicago, IL, 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