{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:46:06Z","timestamp":1792691166123,"version":"4.5.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A wide range of liquid embolic agents has been used in endovascular treatment (EVT) of dural arteriovenous fistulas (dAVFs) and cerebral arteriovenous malformations (cAVMs). Newer liquid embolics, Squid (Balt) and PHIL (MicroVention), aim to improve the safety and efficacy of EVT of dAVFs and cAVMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the safety and efficacy of EVT of cAVMs and dAVFs using Squid or PHIL as an embolic agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched major databases following PRISMA guidelines and included studies with \u2265 five patients reporting on EVT of dAVFs and\/or cAVMs using Squid or PHIL as embolic agent. We analyzed efficacy outcomes including complete occlusion, incomplete occlusion, and recurrence at follow up, and safety outcomes including procedure-related complications, morbidity, and mortality with a random-effects meta-analysis. Separate analyses were performed for cAVMs and dAVFs. Subanalyses were conducted for studies exclusively utilizing PHIL and those exclusively utilizing Squid, for both cAVMs and dAVFs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten studies, comprising 214 patients (53.7% male), were found. Of these, 113 patients had 113 dAVFs, while 101 patients had 101 cAVMs. Complete occlusion rates following embolization were 91% for dAVFs and 32% for cAVMs. A subanalysis of dAVFs embolized solely with Squid and PHIL identified 93% and 86% complete occlusion rates, respectively. The overall procedure-related permanent morbidity rate was 3% for dAVFs and 7% for cAVMs. There was only one procedure-related mortality, which developed in a cAVM case, across 214 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Squid and PHIL are safe and effective embolic agents for treatment of dAVFs and cAVMs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199241288897","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T14:16:37Z","timestamp":1729174597000},"page":"1786-1795","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Safety and efficacy of newer liquid embolic agents Squid and PHIL in endovascular embolization of cerebral arteriovenous malformations and dural arteriovenous fistulas: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-5633","authenticated-orcid":false,"given":"Ahmet","family":"G\u00fcnkan","sequence":"first","affiliation":[{"name":"Fatih Sultan Mehmet Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Yuri","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ninth July University-S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9487-1119","authenticated-orcid":false,"given":"Marina","family":"Vilardo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Catholic University of Brasilia, Brasilia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1316-0383","authenticated-orcid":false,"given":"Luca","family":"Scarcia","sequence":"additional","affiliation":[{"name":"Henri Mondor Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhon E.","family":"Bocanegra-Becerra","sequence":"additional","affiliation":[{"name":"Academic Department of Surgery, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOSA Neuroradiologia Interventistica, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5325-1343","authenticated-orcid":false,"given":"Christian","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Lenox Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-5699","authenticated-orcid":false,"given":"Adam","family":"Dmytriw","sequence":"additional","affiliation":[{"name":"Neuroendovascular Program, Massachusetts General Hospital &amp; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ciccio","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical and Exercise Physiology, CHU Saint-\u00c9tienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Claren\u00e7on","sequence":"additional","affiliation":[{"name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital"},{"name":"GRC BioFast, Sorbonne University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafell","family":"Serulle","sequence":"additional","affiliation":[{"name":"Lenox Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-2870-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.5.JNS16331"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2013.02.064"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx309"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011427"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1085930"},{"key":"e_1_3_3_8_2","first-page":"163","article-title":"A new liquid material for embolization of arteriovenous malformations","volume":"11","author":"Taki W","year":"1990","unstructured":"Taki W, Yonekawa Y, Iwata H, et al. 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