{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T08:44:07Z","timestamp":1785919447061,"version":"3.56.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal treatment for carotid free-floating thrombus (CFFT) remains uncertain due to limited evidence, with no randomized clinical trials and scarce guidelines, such as ESVS 2023, favoring conservative management. Anticoagulation (ACT) and antiplatelet (APT) therapies are emerging as promising alternatives to high-risk surgical interventions. This systematic review aimed to evaluate the safety and efficacy of ACT and APT therapies for CFFT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search was performed across PubMed, Embase, Web of Science, and Cochrane databases. Safety and efficacy endpoints were assessed. A two-sample\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test compared baseline characteristics between groups, and a Chi-square test evaluated differences in categorical variables. Statistical significance was set at\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05. Data were analyzed using R 4.3.0 with the meta package v.7.0-0.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four studies met the inclusion criteria, involving 170 patients diagnosed with CFFT. The APT group included 96 patients (mean age 55.35\u2009\u00b1\u200913.52 years; 56.25% male), and the ACT group included 74 patients (mean age 58.57\u2009\u00b1\u200914.28 years; 51.35% male). Thrombus regression was slightly lower in APT (42%) compared to ACT (48%). Both groups showed similar rates of residual stenosis. Antiplatelet had fewer ischemic events within 30 days (none vs. 4% in ACT) and lower intracranial hemorrhage rates (3.3% vs. 5.4% in ACT) but higher mortality (6.3% vs. none in ACT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both ACT and APT are effective for managing CFFT, each with distinct efficacy and safety profiles. However, randomized trials are necessary to better assess these therapies in CFFT management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199241304164","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T06:12:16Z","timestamp":1733811136000},"page":"1796-1805","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of anticoagulant and antiplatelet therapies in the medical management of carotid free-floating thrombus: A systematic review"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2842-4986","authenticated-orcid":false,"given":"Raphael","family":"Camerotte","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9487-1119","authenticated-orcid":false,"given":"Marina","family":"Vilardo","sequence":"additional","affiliation":[{"name":"School of Medicine, Catholic University of Brasilia, Bras\u00edlia, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1091-6624","authenticated-orcid":false,"given":"Filipe Virgilio","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Bar\u00e3o de Mau\u00e1 University Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-7195","authenticated-orcid":false,"given":"Jhon E","family":"Bocanegra-Becerra","sequence":"additional","affiliation":[{"name":"Univesidad Peruana Cayetano Heredia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ocilio Ribeiro","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Paleare","sequence":"additional","affiliation":[{"name":"School of Medicine, Pontifical Catholic University of Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3269-635X","authenticated-orcid":false,"given":"Saul","family":"Dominici","sequence":"additional","affiliation":[{"name":"Federal University of Maranh\u00e3o"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Parke C","family":"Corvelo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Grande Rio, Duque de Caxias, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Ken","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, FMABC University Center, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Pari","family":"Mitre","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0414-724X","authenticated-orcid":false,"given":"Thierry","family":"Sobral","sequence":"additional","affiliation":[{"name":"Cesmac University Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Yuri","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Lenox Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5325-1343","authenticated-orcid":false,"given":"Christian","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Phelps Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gordon","sequence":"additional","affiliation":[{"name":"Phelps Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Langer","sequence":"additional","affiliation":[{"name":"Lenox Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafell","family":"Serulle","sequence":"additional","affiliation":[{"name":"Lenox Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.09.057"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-010-0738-x"},{"key":"e_1_3_3_4_2","first-page":"1169","article-title":"The appropriate use of carotid endarterectomy","volume":"166","author":"Barnett HJM","year":"2002","unstructured":"Barnett HJM, Meldrum HE, Eliasziw M, et al. 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