{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:55Z","timestamp":1792787755983,"version":"4.5.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["5U54GM104942-08"],"award-info":[{"award-number":["5U54GM104942-08"]}],"id":[{"id":"https:\/\/ror.org\/04q48ey07","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pretreatment CT perfusion (CTP) marker relative cerebral blood volume (rCBV)\u2009&lt;\u200942% lesion volume has recently shown to predict poor collateral status and poor 90-day functional outcome. However, there is a paucity of studies assessing its association with hemorrhagic transformation (HT). Here, we aim to assess the relationship between rCBV\u2009&lt;\u200942% lesion volume with HT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we included patients with acute ischemic stroke secondary to large vessel occlusion (AIS-LVO) of anterior circulation who had successful recanalization from two comprehensive stroke centers between 9\/1\/2017 and 10\/01\/2023. Successful recanalization was defined as modified treatment in cerebral infarction (mTICI) 2b or greater. Logistic regression analysis and ROC analysis were used to assess the relationship between rCBV &lt;42% and HT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 150 patients (median age: 69 years, 58.7% female) met our inclusion criteria. On multivariable logistic regression analysis, taking into account age, sex, hypertension, hyperlipidemia, diabetes, prior stroke or transient ischemic attack, admission National Institute of Health stroke scale (NIHSS), Alberta Stroke Program Early CT Score (ASPECTS), and intravenous thrombolysis, rCBV &lt;34% (aOR:1.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05), rCBV &lt;38% (aOR:1.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05) and rCBV &lt;42% (aOR:1.01,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05) lesion volumes were independently associated with HT. On ROC analysis rCBV\u2009&lt;\u200942% (AUC\u2009=\u20090.61,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05) performed slightly better than rCBV\u2009&lt;\u200938% (AUC\u2009=\u20090.59,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05) and rCBV\u2009&lt;\u200934% (AUC\u2009=\u20090.59,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05) in predicting HT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The rCBV &lt;42% lesion volume is independently associated with HT in AIS-LVO patients who underwent successful recanalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199241308322","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T02:57:16Z","timestamp":1736218636000},"page":"2617-2624","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The relative cerebral blood volume (rCBV)\u2009&lt;\u200942% is independently associated with hemorrhagic transformation in anterior circulation large vessel occlusion"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-1887","authenticated-orcid":false,"given":"Dhairya A","family":"Lakhani","sequence":"first","affiliation":[{"name":"Johns Hopkins University"},{"name":"West Virginia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneri B","family":"Balar","sequence":"additional","affiliation":[{"name":"Johns Hopkins 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