{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:51:56Z","timestamp":1777729916040,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coil embolization is a standard therapeutic approach for intracranial aneurysms. Recurrence risk during follow-up is not negligible, with inadequate packing density identified as a potential risk factor. This study aims to identify patient- and procedure-related factors contributing to recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively enrolled consecutive patients with unruptured intracranial aneurysms treated only with coils between January 2021 and December 2022. Aneurysms were included if 3D-rotational angiography and follow-up imaging were available. For each patient, the volume embolization ratio (VER) was computed using Sim&amp;Size\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (Sim&amp;Cure, France) for both the framing coil (First-coil VER) and the entire coiling procedure (Global VER). Patient demographics and aneurysm characteristics were also recorded. Follow-up imaging classified patients into adequate- or inadequate-occlusion groups. Multivariate analyses assessed independent factors associated with recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy-nine unruptured aneurysms from 79 patients were included. At follow-up,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200969 (87%) demonstrated adequate occlusion, defined as modified Raymond-Roy classification I-II. Adequate- and inadequate-occlusion groups differed in First-coil (13.5\u2009\u00b1\u20095.5% vs 7.1\u2009\u00b1\u20094.0% respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002) and Global VER (24.5\u2009\u00b1\u20096.8% vs 17.3\u2009\u00b1\u20095.7% respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.004). Posterior aneurysm location (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.013), aneurysm height (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.007), and neck diameter (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.018) were significantly associated with recurrence. In multivariate analysis, Global- (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.029) and First-coil VER (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.025) remained significant risk factors for recurrence, with their interaction term being statistically significant as well (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.020).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      First-coil and Global VER computed using Sim&amp;Size\n                      <jats:sup>\u00ae<\/jats:sup>\n                      are predictive of aneurysm occlusion at follow-up. These results highlight the potential value of virtual simulation in optimizing coil packing density to improve mid- to long-term occlusion outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199251341652","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T19:05:42Z","timestamp":1747854342000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interdependence of First-coil and Global volume embolization ratios (VERs) calculated by Sim&amp;Size in predicting aneurysm occlusion outcomes"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6064-4583","authenticated-orcid":false,"given":"Gianfranco","family":"Di Salle","sequence":"first","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Atallah","sequence":"additional","affiliation":[{"name":"Sim&amp;Cure, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-7456","authenticated-orcid":false,"given":"Liesjet EH","family":"van Dokkum","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Gascou","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Dargazanli","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre Henri","family":"Lefevre","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois-Louis","family":"Collemiche","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Varnier","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Checkouri","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Chnafa","sequence":"additional","affiliation":[{"name":"Sim&amp;Cure, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Rene","sequence":"additional","affiliation":[{"name":"Sim&amp;Cure, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razvan Alexandru","family":"Radu","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Costalat","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Cagnazzo","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-017972"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2017.05.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2022.02.009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.869880"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-005-1446-9"},{"issue":"1","key":"e_1_3_3_7_2","first-page":"59","article-title":"Endovascular occlusion of intracranial aneurysms with Guglielmi detachable coils: correlation between coil packing density and coil compaction","volume":"6","author":"Kawanabe1 Y","year":"2001","unstructured":"Kawanabe1 Y, Sadato1 A, Taki W, et al. Endovascular occlusion of intracranial aneurysms with Guglielmi detachable coils: correlation between coil packing density and coil compaction. Interv Neuroradiol 2001; 6(Suppl 1): 59\u201363. doi: https:\/\/doi.org\/10.1177\/15910199000060S106","journal-title":"Interv Neuroradiol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2313030460"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.45.561"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199000060S106"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199010070S121"},{"key":"e_1_3_3_12_2","first-page":"866","article-title":"The volume embolization ratio of intraaneurysmal embolization using guglielmi detachable coils","volume":"25","author":"Zhang Y","year":"2015","unstructured":"Zhang Y, Xing X, Shen X, et al. The volume embolization ratio of intraaneurysmal embolization using guglielmi detachable coils. Original Investigation Turk Neurosurg 2015; 25: 866\u2013872.","journal-title":"Original Investigation Turk Neurosurg"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199060120S114"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164106X98044"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-015-0658-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2016-012877"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-018-0710-4"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3171\/2015.7.JNS15238"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs0901.095600"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199231155288"},{"issue":"53","key":"e_1_3_3_21_2","article-title":"The first coil embolization ratio is the key factor for retreatment for unruptured cerebral aneurysms","volume":"14","author":"Nogami K","year":"2023","unstructured":"Nogami K, Misaki K, Tsutsui T, et al. The first coil embolization ratio is the key factor for retreatment for unruptured cerebral aneurysms. 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