{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:53:15Z","timestamp":1777729995238,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T00:00:00Z","timestamp":1752364800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stent-assisted coiling (SAC) is increasingly used to treat ruptured wide-necked intracranial aneurysms. The pEGASUS-HPC stent, featuring a hydrophilic polymer coating (HPC) to reduce thrombogenicity, may offer a safe option in subarachnoid hemorrhage (SAH). This study evaluates its safety and efficacy in a multicenter retrospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between July 2021 and June 2024, 22 patients with ruptured wide-necked aneurysms were treated with pEGASUS-HPC SAC at four neurovascular centers. Procedural success, aneurysm occlusion (Modified Raymond-Roy Classification, MRRC), and clinical outcomes based on the modified Rankin Scale (mRS) at discharge and follow-up were assessed. Complications and mortality were analyzed in relation to clinical and procedural factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Stent implantation and coil embolization were successfully performed in all patients. Immediate complete occlusion (MRRC I) was achieved in 19 cases (86.4%) and reached 100% at the 3-month follow-up. The median mRS improved from 3 (2\u20135) at discharge to 0 (0\u20132) at 3 months and 0 (0\u20131) at final follow-up, indicating sustained recovery. In 27.3% of cases, Y-stenting was required, reflecting bifurcation complexity. One patient (4.6%) had transient in-stent thrombosis, which resolved with tirofiban. All complications were minor and managed conservatively. No retreatment was required. All three deaths (13.6%) occurred in patients with Hunt and Hess grade V and basilar artery aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The pEGASUS-HPC stent showed a favorable safety profile with high occlusion and recovery rates in ruptured wide-necked aneurysms. These findings support the use of surface-modified stents in the acute setting and highlight the need for prospective studies to confirm long-term safety and efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199251357993","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T06:32:31Z","timestamp":1752474751000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Stent-assisted coiling using the pEGASUS-HPC stent for acutely ruptured wide-necked intracranial aneurysms: A multicenter retrospective study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2819-4623","authenticated-orcid":false,"given":"Abdallah","family":"Aburub","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakarya","family":"Ali","sequence":"additional","affiliation":[{"name":"Central Institute for Diagnostic and Interventional Radiology, Neuroradiology, and Nuclear Medicine, Sana Klinikum Offenbach, Offenbach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Khanafer","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum Stuttgart \u2013 Katharinenhospital, Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-0688","authenticated-orcid":false,"given":"Tawfik","family":"Moher Alsady","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany"},{"name":"Department of Neuroradiology, Rh\u00f6n Klinikum, Campus Bad Neustadt, Bad Neustadt an der Saale, Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oussama","family":"Dob","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-9410","authenticated-orcid":false,"given":"Christopher","family":"Nimsky","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Grote","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5049-0200","authenticated-orcid":false,"given":"Bayan","family":"Alhaj Mouatafa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Korth\u00e4uer","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology and Neuroradiology, Stiftungsklinikum Mittelrhein Koblenz, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Felber","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology and Neuroradiology, Stiftungsklinikum Mittelrhein Koblenz, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-036X","authenticated-orcid":false,"given":"Hans","family":"Henkes","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Klinikum Stuttgart \u2013 Katharinenhospital, Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Kemmling","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany"},{"name":"Department of Neuroradiology, Rh\u00f6n Klinikum, Campus Bad Neustadt, Bad Neustadt an der Saale, Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4233-8048","authenticated-orcid":false,"given":"Mohammad","family":"Almohammad","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, University Hospital Marburg, Philipps-University Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-019-08537-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2024-021732"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67214-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-156"},{"key":"e_1_3_3_6_2","article-title":"Surgical clipping versus endovascular coiling in the management of intracranial aneurysms","volume":"13","author":"Belavadi R","year":"2021","unstructured":"Belavadi R, Gudigopuram SVR, Raguthu CC, et al. 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J Neurointerv Surg 2024; 17: e152\u2013e158.","journal-title":"J Neurointerv Surg"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2024-021737"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019919858000"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-018-2036-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.5469\/neuroint.2024.00066"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/2019.3.JNS183160"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019920945059"},{"key":"e_1_3_3_18_2","first-page":"159101992513480","article-title":"pEGASUS HPC stent pusher-assisted catheterization (PAC) of nonruptured cerebral aneurysms: safety and efficacy","volume":"31","author":"Alhaj Moustafa B","year":"2025","unstructured":"Alhaj Moustafa B, Khanafer A, Dadak M, et al. pEGASUS HPC stent pusher-assisted catheterization (PAC) of nonruptured cerebral aneurysms: safety and efficacy. 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