{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:53:32Z","timestamp":1777730012110,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Mechanical thrombectomy (MT) is the gold standard for treating large vessel occlusions. Given the variability in vessel anatomy among patients and the sometimes arbitrary selection of devices by neurointerventionalists, the choice of microcatheter size requires thorough evaluation. We aim to evaluate the impact of device-to-vessel size ratio on periprocedural distal embolization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Fragment-prone clot analogs (length\u2009=\u20099.86\u00b10.07 mm) were used to embolize three different vessels (lumen\u2009=\u20092.0, 2.5, 3.5 mm) in a three-dimensional-printed neurovascular model. Three different microcatheter sizes (0.017\u2033, 0.021\u2033, 0.027\u2033) were used to cross the lesion and subsequently, migrated clot fragments were collected in an outflow filter for image analysis. Experiments were conducted both with and without a microguidewire. A total of 180 experiments were performed: 60 for each M1 segment of middle cerebral artery size, including 20 for each microcatheter\u201410 with J-shaped microguidewire and 10 without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across all vessels, the 0.027\u2033 microcatheter caused more distal embolizations compared to 0.017\u2033 (p\u2009=\u20090.04) and 0.021\u2033 (p\u2009=\u20090.01). In the 2 mm M1-MCA, 0.017\u2033 microcatheter reduced emboli compared to 0.021\u2033 (p = 0.062) and 0.027\u2033 (p\u2009=\u20090.017). Procedures in the 2 mm vessel are significantly more prone to embolization compared to larger M1 segments (p\u2009&lt;\u20090.05). Microcatheter-to-vessel ratio \u22650.38 significantly increases risk of distal embolization. The use of microguidewire in the procedures did not have any impact on distal embolization (p\u2009=\u20090.871).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A larger device-to-vessel size ratio induces an increase in distal embolization. Neurointerventionalists should carefully consider vessel anatomy for appropriate microcatheter size selection to minimize the risk of distal embolization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199251359359","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T08:53:41Z","timestamp":1753692821000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of microcatheter-to-vessel size ratio on distal embolization during mechanical thrombectomy\u2014an in vitro quantitative study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-3731","authenticated-orcid":false,"given":"Riccardo","family":"Tiberi","sequence":"first","affiliation":[{"name":"Stroke Research, Vall d\u2019Hebron Research Institute, Barcelona, Catalunya, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-8222","authenticated-orcid":false,"given":"Jiahui","family":"Li","sequence":"additional","affiliation":[{"name":"Stroke Research, Vall d\u2019Hebron Research Institute, Barcelona, Catalunya, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-7977","authenticated-orcid":false,"given":"Magda","family":"Jablonska","sequence":"additional","affiliation":[{"name":"Stroke Research, Vall d\u2019Hebron Research Institute, Barcelona, Catalunya, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan Daniel","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Vall d'Hebron University Hospital, Barcelona, Catalunya, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-1535","authenticated-orcid":false,"given":"Alejandro","family":"Tomasello","sequence":"additional","affiliation":[{"name":"Stroke Research, Vall d\u2019Hebron Research Institute, Barcelona, Catalunya, Spain"},{"name":"Department of Neuroradiology, Vall d'Hebron University Hospital, Barcelona, Catalunya, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-043X","authenticated-orcid":false,"given":"Marc","family":"Ribo","sequence":"additional","affiliation":[{"name":"Stroke Research, Vall d\u2019Hebron Research Institute, Barcelona, Catalunya, Spain"},{"name":"Stroke Unit, Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Catalunya, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411587"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000480668"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8205"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019887"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014105"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010314"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-7657-3_19"},{"key":"e_1_3_2_9_2","unstructured":"SlicerSolutions. \u201c3D Slicer 4.10.2 \u201d 2019. 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Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199251359359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15910199251359359","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199251359359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:57:09Z","timestamp":1777460229000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15910199251359359"}},"subtitle":["Comparative study of different microcatheter sizes in different neurovascular models"],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":14,"alternative-id":["10.1177\/15910199251359359"],"URL":"https:\/\/doi.org\/10.1177\/15910199251359359","relation":{},"ISSN":["1591-0199","2385-2011"],"issn-type":[{"value":"1591-0199","type":"print"},{"value":"2385-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"article-number":"15910199251359359"}}