{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:14:41Z","timestamp":1787019281018,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      This study presents our initial experience using\n                      <jats:sub>iht<\/jats:sub>\n                      Obtura, a novel nonadhesive liquid embolic agent with extra-low viscosity variants, in transvenous curative embolization of brain arteriovenous malformations (bAVMs). We assess the agent's performance and compare its advantages with other extra-low viscosity options currently available.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Five patients (three females, two males; mean age, 33 years; range, 20\u201355 years) with ruptured bAVMs were treated using the transvenous retrograde pressure cooker technique (TVRPCT). Three patients underwent staged embolization for large bAVMs, with the final session performed using TVRPCT, while two patients with smaller bAVMs were treated in a single session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Complete obliteration was achieved in 100% of patients. The mean volume of\n                      <jats:sub>iht<\/jats:sub>\n                      Obtura used per transvenous session was 7.9\u2005mL (range, 2\u201314\u2005mL)\u2009\u00b1\u20094.8. A combination of\n                      <jats:sub>iht<\/jats:sub>\n                      Obtura 15 and\n                      <jats:sub>iht<\/jats:sub>\n                      Obtura 12 was used in three cases, while\n                      <jats:sub>iht<\/jats:sub>\n                      Obtura 15 alone was used in two cases. Complete angiographic occlusion was sustained at six and 24 months follow-up. Clinical outcomes improved in three patients and remained unchanged in two (mRS\u2009=\u20090).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The TVRPCT with extra-low viscosity\n                      <jats:sub>iht<\/jats:sub>\n                      Obtura appears to be as safe and effective as other extra-low viscosity nonadhesive liquid embolic agents for curative treatment of bAVMs. The penetration, diffusion, and distribution of\n                      <jats:sub>iht<\/jats:sub>\n                      Obtura through the transvenous route were optimal, with no observed vascular rupture or extravasation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199251375532","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T14:50:39Z","timestamp":1757343039000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Transvenous curative embolization of brain arteriovenous malformations using extra-low viscosity\n                    <sub>iht<\/sub>\n                    Obtura versions: Initial experience and technical insights"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5521-2524","authenticated-orcid":false,"given":"Juan Carlos","family":"Llibre-Guerra","sequence":"first","affiliation":[{"name":"Department of Interventional Neuroradiology, University Hospital of Salamanca, Salamanca, Spain"},{"name":"Interventional Neurology Unit, Institute of Neurology and Neurosurgery, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Casta\u00f1o Bl\u00e1zquez","sequence":"additional","affiliation":[{"name":"Interventional Neurology Unit, Institute of Neurology and Neurosurgery, Havana, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Guimaraens","sequence":"additional","affiliation":[{"name":"J.J. Merland Department of Therapeutic Neuroangiography, University General Hospital of Catalonia and Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-3992","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Pumar","sequence":"additional","affiliation":[{"name":"Chair of Interventional Neuroradiology, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5111-1972","authenticated-orcid":false,"given":"Pascal\u202fJ","family":"Mosimann","sequence":"additional","affiliation":[{"name":"Division of Interventional and Diagnostic Neuroradiology, Toronto Western Hospital and University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gil-Garc\u00eda","sequence":"additional","affiliation":[{"name":"J.J. Merland Department of Therapeutic Neuroangiography, University General Hospital of Catalonia and Hospital del Mar, Barcelona, Spain"},{"name":"Department of Interventional Neuroradiology, University Hospital Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.18.04421-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016566"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx581"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.9.JNS141714"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.04.223"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2017-013113"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.10.JNS181791"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-021-01066-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019920954095"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5750"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-021442"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8834"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2024.08.144"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.70355\/NICeR.3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2018.08.024"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199241288897"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199251332400"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014390"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.3.FOCUS18113"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1591019916682357"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015515"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.18.04342-4"},{"key":"e_1_3_3_24_2","first-page":"1744","article-title":"Safety and efficacy of transvenous embolization of ruptured brain arteriovenous malformations as a last resort: a prospective single-arm study","volume":"40","author":"He Y","year":"2019","unstructured":"He Y, Ding Y, Bai W, et al. Safety and efficacy of transvenous embolization of ruptured brain arteriovenous malformations as a last resort: a prospective single-arm study. AJNR Am J Neuroradiol 2019; 40: 1744\u20131751.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015115"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.873186"}],"container-title":["Interventional Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199251375532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15910199251375532","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15910199251375532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:57:18Z","timestamp":1777460238000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15910199251375532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":25,"alternative-id":["10.1177\/15910199251375532"],"URL":"https:\/\/doi.org\/10.1177\/15910199251375532","relation":{},"ISSN":["1591-0199","2385-2011"],"issn-type":[{"value":"1591-0199","type":"print"},{"value":"2385-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]},"article-number":"15910199251375532"}}