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In this correspondence, we highlight emerging evidence suggesting that DMSO exposure may contribute to the development of hydrocephalus through mechanisms involving ependymal damage and astrocyte apoptosis. Drawing on recent experimental findings, we propose that DMSO-induced neuroinflammation may play a role in post-embolization complications. We urge the research community to consider hydrocephalus as a possible, though unproven, outcome of DMSO exposure and to include it in long-term safety assessments of embolic agents.<\/jats:p>","DOI":"10.1177\/15910199251380379","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:06:29Z","timestamp":1758913589000},"page":"2895-2896","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reconsidering dimethyl sulfoxide in endovascular embolization: A potential toxic-dependent contributor to hydrocephalus?"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5787-2032","authenticated-orcid":false,"given":"Leandro","family":"Castaneyra-Ruiz","sequence":"first","affiliation":[{"name":"Research department, CHOC Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Hanak","sequence":"additional","affiliation":[{"name":"CHOC Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sora","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9548-1720","authenticated-orcid":false,"given":"Michael","family":"Le","sequence":"additional","affiliation":[{"name":"Research department, CHOC Children's Hospital, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Muhonen","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, CHOC Children\u2019s Hospital, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40660-0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152538"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199408000-00018"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2012.03.037"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121634"},{"key":"e_1_3_3_7_2","first-page":"163","article-title":"A new liquid material for embolization of arteriovenous malformations","volume":"11","author":"Taki W","year":"1990","unstructured":"Taki W, Yonekawa Y, Iwata H, et al. 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