{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:56:16Z","timestamp":1777730176463,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Preoperative embolization of hypervascular tumors facilitates safer surgical resection by reducing intraoperative bleeding and operative time. ihtOBTURA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      is a novel EVOH-based liquid embolic agent characterized by progressive post-procedural loss of radiopacity due to iodine-based contrast properties. This report presents our initial clinical experience using ihtOBTURA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      for presurgical embolization of hyper vascular tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed 15 patients (mean age 41.3 years; 9 females) undergoing 16 embolization procedures with ihtOBTURA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      between February and September 2022. Collected data included demographics, lesion pathology and location, arterial feeders, embolization technique, number of pedicles, embolic volume (ml), LEA viscosity, percentage angiographic devascularization, CT artifacts, procedural and technical complications, and surgical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tumor types included meningiomas (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20099), juvenile nasal angiofibromas (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20092), carotid body tumors (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20092), glomus jugulare tumor (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091), solitary fibrous tumor (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091), and aneurysmal bone cyst (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091). Complete (100%) or near-complete (&gt;80%) devascularization was achieved in 80% of patients. The median volume of ihtOBTURA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      used was 4.3\u2005ml (range: 1.0\u201313.0\u2005ml). Mean procedure time was 90\u2005min (range: 40\u2013176). Surgical resection was completed in 13\/14 surgical cases, with a median intraoperative blood loss of 462\u2005ml. No major complications related to the embolization procedures were observed. Excellent penetration and diffusion of the ihtOBTURA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      into the tumor was documented through preoperative imaging and operative pathology samples. Post-embolization imaging showed reduced artifacts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      ihtOBTURA\n                      <jats:sup>\u00ae<\/jats:sup>\n                      is an efficient and safe alternative embolic agent for preoperative tumor devascularization.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199251395153","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T18:34:12Z","timestamp":1763577252000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Initial experience with ihtOBTURA\n                    <sup>\u00ae<\/sup>\n                    : A novel EVOH-based embolic agent in the preoperative embolization of hypervascular head, neck, and spinal tumors"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5521-2524","authenticated-orcid":false,"given":"Juan Carlos","family":"Llibre-Guerra","sequence":"first","affiliation":[{"name":"University Hospital of Salamanca"},{"name":"Interventional Neurology Unit, Institute of Neurology and Neurosurgery, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dunier","family":"Abreu Casas","sequence":"additional","affiliation":[{"name":"Institute of Neurology and Neurosurgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes Rita","family":"Salina Olivares","sequence":"additional","affiliation":[{"name":"Institute of Neurology and Neurosurgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Casta\u00f1o Bl\u00e1zquez","sequence":"additional","affiliation":[{"name":"Interventional Neurology Unit, Institute of Neurology and Neurosurgery, Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-3992","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Pumar","sequence":"additional","affiliation":[{"name":"University of Santiago de Compostela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Gil-Garc\u00eda","sequence":"additional","affiliation":[{"name":"University Hospital Marqu\u00e9s de Valdecilla"},{"name":"J.J. Merland Department of Therapeutic Neuroangiography, University General Hospital Of Catalunya and Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo","family":"Guimaraens","sequence":"additional","affiliation":[{"name":"J.J. Merland Department of Therapeutic Neuroangiography, University General Hospital Of Catalunya and Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2212001140"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2014.04.015"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2012-010542"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.02.033"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841850601161547"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000315300.83459.5C"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2022-019080"},{"key":"e_1_3_4_9_2","first-page":"1675","article-title":"Efficacy of endovascular treatment of meningiomas: evaluation with matched samples","volume":"15","author":"Dean BL","year":"1994","unstructured":"Dean BL, Flom RA, Wallace RC, et al. 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First European Completed Case with ihtObtura\u00ae, a Novel Liquid Embolic Agent with Radiopacity Loss. J Neurointerventional Case Rep 2025; 2: \u20133.","journal-title":"J Neurointerventional Case Rep"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/15910199251375532"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2024-022015"},{"key":"e_1_3_4_23_2","unstructured":"St. Olavs Hospital. Embolization for meningioma. ClinicalTrials.gov identifier: NCT05416567. 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