{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:57:20Z","timestamp":1777730240609,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Animal models are essential for evaluating endovascular device safety and efficacy. Rats offer advantages, such as genetic manipulability, lower cost, and shorter healing and breeding cycles, compared to large animals. These features support studying aneurysm healing mechanisms and enable high-throughput testing. We developed an optimal rat aneurysm model for device evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Saccular aneurysms were created at the origins of the left renal artery (LRA) with acetylsalicylic acid (ASA) (LRA\/ASA group, n\u2009=\u20097); the right common iliac artery (RCIA) with ASA alone (RCIA\/ASA group, n\u2009=\u20096) or ASA plus clopidogrel (CLP) (RCIA\/ASA\u2009+\u2009CLP group, n\u2009=\u20097); and the left common iliac artery (LCIA) with ASA\u2009+\u2009CLP (LCIA\/ASA\u2009+\u2009CLP group, n\u2009=\u20097). The origins of these arteries were surgically exposed. During temporary ligation of the vessel origin, the vessel was bisected and endoluminal elastase was incubated in the proximal stump for 10\u2005min, followed by release of the proximal ligation and permanent ligation of the stump. Angiographical and histological analysis were performed 4 weeks post-procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Follow-up digital subtraction angiography revealed mean\u2009\u00b1\u2009standard deviation aneurysm height\/neck dimensions of 1.2\u2009\u00b1\u20090.4\/1.2\u2009\u00b1\u20090.1, 2.9\/3.1, 2.3\u2009\u00b1\u20090.6\/1.9\u2009\u00b1\u20090.3, and 2.1\u2009\u00b1\u20090.6\/2.0\u2009\u00b1\u20090.4\u2005mm for the LRA\/ASA, RCIA\/ASA, RCIA\/ASA\u2009+\u2009CLP, and LCIA\/ASA\u2009+\u2009CLP groups, respectively. The survival rate was 29%, 17%, 71%, and 86% in the LRA\/ASA, RCIA\/ASA, RCIA\/ASA\u2009+\u2009CLP, and LCIA\/ASA\u2009+\u2009CLP groups, respectively. Histopathological analysis of these aneurysms confirmed the absence of the internal elastic lamina and revealed aneurysmal changes in the arterial wall, resembling the pathological findings observed in human aneurysm specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Common iliac aneurysm models with ASA + CLP can be used to evaluate the safety and efficacy of endovascular devices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15910199251399755","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:45:16Z","timestamp":1765817116000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a novel elastase-induced saccular aneurysm model in rats suitable for testing endovascular devices: An experimental animal study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5708-3380","authenticated-orcid":false,"given":"Yasuhito","family":"Ueki","sequence":"first","affiliation":[{"name":"Mayo Clinic"},{"name":"Department of Neurosurgery, Graduate School of Medicine, the University of Juntendo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-2689","authenticated-orcid":false,"given":"Esref A","family":"Bayraktar","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Ognard","sequence":"additional","affiliation":[{"name":"Mayo Clinic"},{"name":"Univ of Brest, LATIM, INSERM UMR1101, CHU Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-8280","authenticated-orcid":false,"given":"Gerard El","family":"Hajj","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4329-3192","authenticated-orcid":false,"given":"Yong H","family":"Ding","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4051-6450","authenticated-orcid":false,"given":"Daying","family":"Dai","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-9953","authenticated-orcid":false,"given":"Ram","family":"Kadirvel","sequence":"additional","affiliation":[{"name":"Mayo Clinic"},{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8495-0040","authenticated-orcid":false,"given":"David F","family":"Kallmes","sequence":"additional","affiliation":[{"name":"Mayo Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015702"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.2.1740349"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-006-0093-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2666"},{"key":"e_1_3_3_6_2","first-page":"2364","article-title":"Can neck size in elastase-induced aneurysms be controlled? 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