{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:09:39Z","timestamp":1777943379656,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2016,12]]},"abstract":"\n Purpose<\/jats:title>\n To evaluate cellular activity in milled versus unmilled surface of the femoral head in 21 patients who underwent robot-assisted total hip arthroplasty (THA).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The femoral head of 21 consecutive patients who underwent robot-assisted THA for osteonecrosis was used. 10 cc of trabecular bone from the entire milled surface was obtained using a curette. The same amount of trabecular bone was obtained at least 1 cm away from the milled surface and served as a matched control. Cell morphology, viability, osteocalcin activity, and alkaline phosphatase activity in milled versus unmilled surface were assessed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Cell morphology of the milled or unmilled surface was comparable; cells were smaller in the milled surface. Cell viability was a mean of 40% higher in the milled surface (107.4% vs. 67.2%, p<0.001); cell viability at 5 time points was comparable in each group. Osteocalcin activity of cells was slightly higher in the milled surface (1.43 vs. 1.24 ng\/ml, p=0.69). Alkaline phosphatase activity of cells was slightly higher in the unmilled surface (150 105 vs. 141 789 U\/L, p=0.078).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The milled and unmilled surfaces of the femoral head were comparable in terms of cell morphology, viability, osteocalcin activity, and alkaline phosphatase activity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1602400320","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T12:28:34Z","timestamp":1485001714000},"page":"370-373","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell Morphology, Viability, Osteocalcin Activity, and Alkaline Phosphatase Activity in Milled versus Unmilled Surface of the Femoral Head"],"prefix":"10.1177","volume":"24","author":[{"given":"Kee Hyung","family":"Rhyu","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, College of Medicine, Kyung Hee University, Kyung Hee University Hospital at Gangdong, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Kyunghee-daero, Dongdaemun-gu, Seoul, Korea"},{"name":"Department of Biochemistry and Molecular Biology (BK21 project); Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Kyunghee-daero, Dongdaemun-gu, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Sik","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Kyunghee-daero, Dongdaemun-gu, Seoul, Korea"},{"name":"Department of Biochemistry and Molecular Biology (BK21 project); Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Kyunghee-daero, Dongdaemun-gu, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Soo","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, College of Medicine, Kyung Hee University, Kyung Hee University Hospital at Gangdong, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"bibr1-1602400320","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00003086-199401000-00007","volume":"298","author":"Bourne RB","year":"1994","journal-title":"Clin Orthop Relat Res"},{"key":"bibr2-1602400320","doi-asserted-by":"publisher","DOI":"10.1016\/0883-5403(92)90042-O"},{"key":"bibr3-1602400320","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199701000-00021"},{"key":"bibr4-1602400320","first-page":"63","volume":"261","author":"Engh CA","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"bibr5-1602400320","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199012000-00006"},{"key":"bibr6-1602400320","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199307000-00049"},{"key":"bibr7-1602400320","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199809000-00011"},{"key":"bibr8-1602400320","first-page":"57","volume":"285","author":"Paul HA","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"bibr9-1602400320","doi-asserted-by":"publisher","DOI":"10.1016\/0883-5403(94)90053-1"},{"key":"bibr10-1602400320","doi-asserted-by":"publisher","DOI":"10.3109\/10929089809148153"},{"key":"bibr11-1602400320","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-5403(96)80129-X"},{"key":"bibr12-1602400320","doi-asserted-by":"publisher","DOI":"10.1007\/s001320050092"},{"key":"bibr13-1602400320","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s001130050177","volume":"100","author":"B\u00f6rner M","year":"1997","journal-title":"Unfallchirurg"},{"key":"bibr14-1602400320","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.4.13.2210157"},{"key":"bibr15-1602400320","first-page":"258","volume":"16","author":"Hauschka PV","year":"1986","journal-title":"Haemostasis"},{"key":"bibr16-1602400320","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.08.018"},{"key":"bibr17-1602400320","doi-asserted-by":"crossref","unstructured":"Aubin JE. 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