{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:34:19Z","timestamp":1785774859544,"version":"3.56.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Risk factors for wound complications or 30-day mortality after major amputation in patients with peripheral arterial disease remain unclear. We investigated the outcomes of major amputation in patients with peripheral arterial disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent major amputation from 2008 to 2015 were retrospectively analyzed. The main outcome measures were risk factors for wound complications and 30-day mortality after major lower limb amputations. Major amputation was defined as above-knee amputation or below-knee amputation. Wound complications were defined as surgical site infection or wound dehiscence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 106 consecutive patients underwent major amputation. The average age was 77.3\u2009\u00b1\u200911.2 years, 67.9% of patients had diabetes mellitus and 35.8% were undergoing hemodialysis. Patients who underwent primary amputation constituted 61.9% of the cohort, and the proportions of above-knee amputation and below-knee amputation were 66.9% and 33.1%, respectively. The wound complication rate was 13.3% overall, 10.3% in above-knee amputation, and 19.5% in below-knee amputation. Multivariate analysis showed that the risk factors for wound complications were female sex (hazard ratio, 4.66; 95% confidence interval, 1.40\u201317.3; P\u2009=\u20090.01) and below-knee amputation (hazard ratio, 4.36; 95% confidence interval, 1.20\u201317.6; P\u2009=\u20090.03). The 30-day mortality rate was 7.6%, pneumonia comprised the most frequent cause of 30-day mortality, followed by sepsis and cardiac death. Multivariate analysis showed that a low serum albumin concentration (hazard ratio, 3.87; 95% confidence interval, 1.12\u201316.3; P\u2009=\u20090.03) was a risk factor for 30-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Female sex and below-knee amputation were risk factors for wound complications. A low serum albumin concentration was a risk factor for 30-day mortality after major amputation in Japanese patients with peripheral arterial disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1708538117714197","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T01:36:33Z","timestamp":1496799393000},"page":"12-17","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Risk factors for wound complications and 30-day mortality after major lower limb amputations in patients with peripheral arterial disease"],"prefix":"10.1177","volume":"26","author":[{"given":"Koichi","family":"Morisaki","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Matsuyama Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terutoshi","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Matsuyama Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuomi","family":"Iwasa","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Matsuyama Red Cross Hospital, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"bibr1-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"bibr2-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.09.044"},{"key":"bibr3-1708538117714197","first-page":"2","volume":"29","author":"Shigematsu H","year":"2010","journal-title":"Int Angiol"},{"key":"bibr4-1708538117714197","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.14-00070"},{"key":"bibr5-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.03.024"},{"key":"bibr6-1708538117714197","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.13-00059"},{"key":"bibr7-1708538117714197","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1177\/000313480206800710","volume":"68","author":"Toursarkissian B","year":"2002","journal-title":"Am Surg"},{"key":"bibr8-1708538117714197","first-page":"14","volume":"103","author":"Stone PA","year":"2007","journal-title":"W V Med J"},{"key":"bibr9-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.12.041"},{"key":"bibr10-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.12.002"},{"key":"bibr11-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.02.019"},{"key":"bibr12-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.01.034"},{"key":"bibr13-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.07.053"},{"key":"bibr14-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2015.10.001"},{"key":"bibr15-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2012.06.030"},{"key":"bibr16-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.07.017"},{"key":"bibr17-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2011.05.019"},{"key":"bibr18-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.115359"},{"key":"bibr19-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.01.042"},{"key":"bibr20-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2012.09.083"},{"key":"bibr21-1708538117714197","doi-asserted-by":"crossref","unstructured":"Morisaki K, Matsumoto T, Matsubara Y, et\u00a0al. Prognostic factor of the two-year mortality after revascularization in patients with critical limb ischemia.\n                      Vascular\n                      2017; 25: 123\u2013129.","DOI":"10.1177\/1708538116651216"},{"key":"bibr22-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1515\/pjs-2016-0023"},{"key":"bibr23-1708538117714197","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000486"}],"container-title":["Vascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538117714197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1708538117714197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538117714197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:30:31Z","timestamp":1777707031000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1708538117714197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,6]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1177\/1708538117714197"],"URL":"https:\/\/doi.org\/10.1177\/1708538117714197","relation":{},"ISSN":["1708-5381","1708-539X"],"issn-type":[{"value":"1708-5381","type":"print"},{"value":"1708-539X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,6]]}}}