{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:13:44Z","timestamp":1777943624816,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The clinical condition of frailty is a common problem in the elderly population. However, the relationship between peripheral artery disease and frailty in hemodialysis patients remains unknown. The aim of this study was to identify the relationships between peripheral artery disease and frailty in Japanese chronic hemodialysis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 362 chronic hemodialysis patients who regularly visited six institutions were enrolled. To evaluate frailty, the modified Fried\u2019s frailty phenotype adjusted for Japanese were used. Peripheral artery disease was defined as ankle-brachial index\u2009&lt;0.9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 362 patients, 62 patients (17.1%) were categorized as peripheral artery disease group and 300 patients (82.9%) as Non-peripheral artery disease group. The prevalence of frailty in the peripheral artery disease group was significantly higher than in the Non-peripheral artery disease group (34% vs. 18%, P\u2009=\u20090.0103). Non-shunt side grip strength was significantly stronger in the Non-peripheral artery disease group (23.6\u2009kg vs. 17.0\u2009kg, P\u2009&lt;\u20090.0001). Thigh circumferences were also significantly larger in the Non-peripheral artery disease group (41.7\u2009cm vs. 39.7\u2009cm, P\u2009=\u20090.0054). A multivariate logistic regression analysis demonstrated that the factors independently associated with peripheral artery disease were as follows: frailty (odds ratio\u2009=\u20092.06, 95% confidence interval 1.09\u20133.89) and myocardial infarction (odds ratio\u2009=\u20093.74, 95% confidence interval 2.05\u20136.83).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It is concluded that peripheral artery disease is closely associated with frailty in hemodialysis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1708538118756690","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T01:54:00Z","timestamp":1517882040000},"page":"425-431","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Peripheral artery disease is associated with frailty in chronic hemodialysis patients"],"prefix":"10.1177","volume":"26","author":[{"given":"Michihiro","family":"Okuyama","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Okayama University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"},{"name":"Department of Internal Medicine, Innoshima General Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7629-7678","authenticated-orcid":false,"given":"Haruhito A","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kakio","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoko","family":"Umebayashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Wada","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis, Department of Internal Medicine, Nippon Kokan Fukuyama Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Human Resource Development of Dialysis Therapy for Kidney Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Rakugi","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Okayama University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"bibr1-1708538118756690","unstructured":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015.\n         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1603\u20131658."},{"key":"bibr3-1708538118756690","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14876"},{"key":"bibr4-1708538118756690","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62167-9"},{"key":"bibr5-1708538118756690","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53405.x"},{"key":"bibr6-1708538118756690","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.6.589"},{"key":"bibr7-1708538118756690","doi-asserted-by":"publisher","DOI":"10.1097\/psy.0b013e318068de1d"},{"key":"bibr8-1708538118756690","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu540"},{"key":"bibr9-1708538118756690","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-015-1112-z"},{"key":"bibr10-1708538118756690","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"bibr11-1708538118756690","doi-asserted-by":"crossref","unstructured":"Takeuchi H, Uchida HA, Kakio Y, et\u00a0al. The prevalence of frailty and its associated factors in japanese hemodialysis patients.\n                      Agin Dis\n                      . Early edition. 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