{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:13:51Z","timestamp":1777943631171,"version":"3.51.4"},"reference-count":103,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["17-75-30009"],"award-info":[{"award-number":["17-75-30009"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This paper describes and analyzes the cellular and molecular mechanisms underlying atherosclerosis development. In particular, the roles of monocytes\/macrophages, smooth muscle cells, and vascular endothelium in the formation of stable\/unstable atheromatous plaques, and the contributions of some processes to atheroma formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this study we analyzed endothelium: function, dysfunction, and involvement into atherogenesis; cell proteins mediating mechanotransduction; proatherogenic role of monocytes; the role of macrophages in the development of unstable atheromatous plaques and smooth muscle cell origin in atherosclerosis. Smooth muscle cell phenotypic switching; their functioning; the ability to retain cholesterol and lipoproteins as well as secretion of pro- and anti-inflammatory molecules and extracellular matrix proteins, their response to extracellular stimuli secreted by other cells, and the effect of smooth muscle cells on the cells surrounding atheromatous plaques are fundamentally important for the insight into atherosclerosis molecular basis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Atheromatous plaque transcriptome studies will be helpful in the identification of the key genes involved in atheroma transformation and development as well as discovery of the new targets for diagnosis and therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1708538118796063","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T01:03:16Z","timestamp":1535590996000},"page":"98-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["The roles of mechanotransduction, vascular wall cells, and blood cells in atheroma induction"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5890-2646","authenticated-orcid":false,"given":"Olga A","family":"Novikova","sequence":"first","affiliation":[{"name":"Department of Vascular and Hybrid Surgery, National Medical Research Institute Academician E.N. Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel P","family":"Laktionov","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine, SB RAS Institute of Chemical Biology and Fundamental Medicine; E.N. Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk, Russian Federation"},{"name":"E.N. Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey A","family":"Karpenko","sequence":"additional","affiliation":[{"name":"Department of Vascular and Hybrid Surgery, National Medical Research Institute Academician E.N. Meshalkin National Medical Research Center, Ministry of Health of Russian Federation, Novosibirsk, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"bibr1-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.052"},{"key":"bibr2-1708538118796063","unstructured":"European Cardiovascular Disease Statistics. European Heart Network. http:\/\/www.ehnheart.org\/images\/CVD-statistics-report-August-2017.pdf (2017, accessed 14 December 2017)."},{"key":"bibr3-1708538118796063","unstructured":"World Health Organization. Cardiovascular diseases (CVDs). http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds) (2017, accessed 14 December 2017)."},{"key":"bibr4-1708538118796063","unstructured":"Rozhkova TI.\n                      Clinical and epidemiological analysis of medical assistance to stroke cases in individual regions of the Russian Federation (according to hospital log data)\n                      . PhD Thesis, Russian State Medical University, Moscow, 2010."},{"key":"bibr5-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.08.011"},{"key":"bibr6-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306361"},{"key":"bibr7-1708538118796063","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2016.06.01"},{"key":"bibr8-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.15.1845"},{"key":"bibr9-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.065"},{"key":"bibr10-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705013361802"},{"key":"bibr11-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.21.2110"},{"key":"bibr12-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1701"},{"key":"bibr13-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1262"},{"key":"bibr14-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-200109000-00006"},{"key":"bibr15-1708538118796063","volume-title":"Vascular biology in clinical practice","author":"Houston MC.","year":"2001"},{"key":"bibr16-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"bibr17-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1115\/1.3138275"},{"key":"bibr18-1708538118796063","first-page":"75","volume":"58","year":"2006","journal-title":"Pharmacol Rep"},{"key":"bibr19-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00625.2003"},{"key":"bibr20-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6525"},{"key":"bibr21-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.154252"},{"key":"bibr22-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt096"},{"key":"bibr23-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302213"},{"key":"bibr24-1708538118796063","doi-asserted-by":"publisher","DOI":"10.2174\/1877382601003010085"},{"key":"bibr25-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu353"},{"key":"bibr26-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000105054.43931.f0"},{"key":"bibr27-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2009"},{"key":"bibr28-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn024"},{"key":"bibr29-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.541573"},{"key":"bibr30-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1656-4"},{"key":"bibr31-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303883"},{"key":"bibr32-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.05.001"},{"key":"bibr33-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2442-4"},{"key":"bibr34-1708538118796063","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060860"},{"key":"bibr35-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1159\/000457797"},{"key":"bibr36-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000267856.00713.0a"},{"key":"bibr37-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301925"},{"key":"bibr38-1708538118796063","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2014.0078"},{"key":"bibr39-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2012.06.006"},{"key":"bibr40-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66056"},{"key":"bibr41-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1097\/01.mol.0000180167.15820.ae"},{"key":"bibr42-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.216283"},{"key":"bibr43-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303879"},{"key":"bibr44-1708538118796063","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00628"},{"key":"bibr45-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394624-9.00002-6"},{"key":"bibr46-1708538118796063","doi-asserted-by":"publisher","DOI":"10.4161\/sgtp.28650"},{"key":"bibr47-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.07.015"},{"key":"bibr48-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409233111"},{"key":"bibr49-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413725111"},{"key":"bibr50-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.024"},{"key":"bibr51-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303299"},{"key":"bibr52-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170689"},{"key":"bibr53-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.168690"},{"key":"bibr54-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000394"},{"key":"bibr55-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.181743"},{"key":"bibr56-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007402"},{"key":"bibr57-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305825"},{"key":"bibr58-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-015-0491-8"},{"key":"bibr59-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200010000-00008"},{"key":"bibr60-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000351"},{"key":"bibr61-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx723"},{"key":"bibr62-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.09.001"},{"key":"bibr63-1708538118796063","doi-asserted-by":"publisher","DOI":"10.2174\/138945011795378522"},{"key":"bibr64-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00978.x"},{"key":"bibr65-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302153"},{"key":"bibr66-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12219"},{"key":"bibr67-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.03.055"},{"key":"bibr68-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087552"},{"key":"bibr69-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0667-3"},{"key":"bibr70-1708538118796063","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2016.49.10.115"},{"key":"bibr71-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.054"},{"key":"bibr72-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410851111"},{"key":"bibr73-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318580"},{"key":"bibr74-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230720"},{"key":"bibr75-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-010-0516-6"},{"key":"bibr76-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.03.059"},{"key":"bibr77-1708538118796063","first-page":"916","volume":"4","author":"Pansuria M","year":"2012","journal-title":"Front Biosci (Schol Ed)"},{"key":"bibr78-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.03.003"},{"key":"bibr79-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.06.038"},{"key":"bibr80-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.025"},{"key":"bibr81-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200904060"},{"key":"bibr82-1708538118796063","first-page":"371","volume":"18","author":"Li J","year":"2012","journal-title":"Mol Vis"},{"key":"bibr83-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.09.004"},{"key":"bibr84-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524292113"},{"key":"bibr85-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs301"},{"key":"bibr86-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1038\/nature18935"},{"key":"bibr87-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.01.015"},{"key":"bibr88-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.19.1960"},{"key":"bibr89-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64415-X"},{"key":"bibr90-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.5.1223"},{"key":"bibr91-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.186064"},{"key":"bibr92-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.028"},{"key":"bibr93-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.183053"},{"key":"bibr94-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.011"},{"key":"bibr95-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000147961.09840.fb"},{"key":"bibr96-1708538118796063","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2017.00002"},{"key":"bibr97-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1113\/JP270033"},{"key":"bibr98-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2010.12.001"},{"key":"bibr99-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.722355"},{"key":"bibr100-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.11.158"},{"key":"bibr101-1708538118796063","doi-asserted-by":"crossref","first-page":"117","DOI":"10.52571\/PTQ.v14.n27.2017.117_Periodico27_pgs_117_122.pdf","volume":"14","author":"Herrmann F","year":"2017","journal-title":"Peri\u00f3dico Tch\u00ea Qu\u00edmica"},{"key":"bibr102-1708538118796063","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305044"},{"key":"bibr103-1708538118796063","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17001"}],"container-title":["Vascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538118796063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1708538118796063","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538118796063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:31:25Z","timestamp":1777707085000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1708538118796063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":103,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1177\/1708538118796063"],"URL":"https:\/\/doi.org\/10.1177\/1708538118796063","relation":{},"ISSN":["1708-5381","1708-539X"],"issn-type":[{"value":"1708-5381","type":"print"},{"value":"1708-539X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]}}}