{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:13:47Z","timestamp":1777943627922,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Carotid stenosis with crescendo-transient-ischemic-attack (cTIA) requires a prompt intervention to reduce the stroke risk. Few data are reported in literature about cTIA suggesting a different perioperative risk compared with patients with single TIA (sTIA). This study aimed to compare the outcome of carotid endarterectomy (CEA) in patients with TIA (single\/crescendo) and evaluate the outcome risk-factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from two tertiary hospitals for vascular treatment were analyzed from 2007 to 2016. All patients with TIA subjected to CEA were considered, comparing the 30-day postoperative stroke and stroke\/death in patients with cTIA and sTIA, particularly in the urgent (\u226448 h) setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On a total of 3866 CEA, 888 (23%) were performed in symptomatic patients and 515 for TIA: 365 (71%) patients with sTIA and 150 (29%) with cTIA. When compared with sTIA, cTIA patients were younger and less frequently affected by coronary disease, dyslipidemia, and chronic pulmonary disease; however, contralateral carotid occlusion was more common (20% vs. 10%, P\u2009=\u2009.004; 56% vs. 46, P\u2009=\u2009.03; 16% vs. 7%, P\u2009=\u2009.01; &gt;80 years 26% vs. 16%, P\u2009=\u2009.01 and 2% vs. 10%, P\u2009=\u2009.001; respectively). Postoperative stroke and stroke\/death were significantly higher in cTIA compared with sTIA (5.3% vs. 1.6%, P\u2009=\u2009.02 and 6.0% vs. 2.2%, P\u2009=\u2009.03; respectively). Urgent CEA was performed in 58% ( n: 87) cTIA and in 11% ( n: 56) sTIA( P&lt;.01). The urgent setting did not influence the stroke and stroke\/death rate of CEA for sTIA (3.6% vs. 1.3%, P\u2009=\u2009.21 and 3.6% vs. 1.9%, P\u2009=\u2009.44, respectively), but was associated with lower rate of events in cTIA (1.1%vs. 11.1%, P\u2009=\u2009.01 and 2.3% vs. 11.1%, P\u2009=\u2009.03, respectively). This beneficial effect in patients with cTIA treated within 48-h was confirmed also by multivariate analysis (OR: 0.09, 95% CI: 0.76\u20130.01, P=.02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>cTIA subjected to CEA have a higher stroke and stroke\/death risk compared with patients with sTIA. The urgent setting seems to reduce the stroke\/death rate cTIA; for sTIA with a stable neurological condition, the timing of CEA did not influence the outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1708538118799225","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T02:24:02Z","timestamp":1536373442000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The different scenarios of urgent carotid revascularization for crescendo and single transient ischemic attack"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6459-1135","authenticated-orcid":false,"given":"Rodolfo","family":"Pini","sequence":"first","affiliation":[{"name":"Vascular Surgery, University of Bologna \u201cAlma Mater Studiorum\u201d, Policlinico S. Orsola Malpighi, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Faggioli","sequence":"additional","affiliation":[{"name":"Vascular Surgery, University of Bologna \u201cAlma Mater Studiorum\u201d, Policlinico S. Orsola Malpighi, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Gargiulo","sequence":"additional","affiliation":[{"name":"Vascular Surgery, University of Bologna \u201cAlma Mater Studiorum\u201d, Policlinico S. Orsola Malpighi, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Gallitto","sequence":"additional","affiliation":[{"name":"Vascular Surgery, University of Bologna \u201cAlma Mater Studiorum\u201d, Policlinico S. Orsola Malpighi, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M","family":"Cacioppa","sequence":"additional","affiliation":[{"name":"Vascular Surgery, University of Bologna \u201cAlma Mater Studiorum\u201d, Policlinico S. Orsola Malpighi, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Vacirca","sequence":"additional","affiliation":[{"name":"Vascular Surgery, University of Bologna \u201cAlma Mater Studiorum\u201d, Policlinico S. Orsola Malpighi, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Pisano","sequence":"additional","affiliation":[{"name":"Vascular Surgery, Ospedale Maggiore, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pilato","sequence":"additional","affiliation":[{"name":"Vascular Surgery, Ospedale Maggiore, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Stella","sequence":"additional","affiliation":[{"name":"Vascular Surgery, University of Bologna \u201cAlma Mater Studiorum\u201d, Policlinico S. Orsola Malpighi, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"bibr1-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.07.004"},{"key":"bibr2-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010764"},{"key":"bibr3-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(96)70152-0"},{"key":"bibr4-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900640"},{"key":"bibr5-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(03)00333-7"},{"key":"bibr6-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2006.137547"},{"key":"bibr7-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.02.005"},{"key":"bibr8-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.524785"},{"key":"bibr9-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.09.055"},{"key":"bibr10-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.11.144"},{"key":"bibr11-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.02.015"},{"key":"bibr12-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811123392002"},{"key":"bibr13-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.12.049"},{"key":"bibr14-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.12.048"},{"key":"bibr15-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.08.077"},{"key":"bibr16-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2012.12.003"},{"key":"bibr17-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(93)90410-N"},{"key":"bibr18-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.003390"},{"key":"bibr19-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.11.006"},{"key":"bibr20-1708538118799225","first-page":"E76","volume":"181","author":"Brott TG","year":"2013","journal-title":"Catheter Cardiovasc Interv"},{"key":"bibr21-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.558528"},{"key":"bibr22-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.09.006"},{"key":"bibr23-1708538118799225","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2491071644"},{"key":"bibr24-1708538118799225","first-page":"1565","volume":"29","author":"Fittipaldi S","year":"2014","journal-title":"Histol Histopathol"}],"container-title":["Vascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538118799225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1708538118799225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538118799225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:31:31Z","timestamp":1777707091000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1708538118799225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1177\/1708538118799225"],"URL":"https:\/\/doi.org\/10.1177\/1708538118799225","relation":{},"ISSN":["1708-5381","1708-539X"],"issn-type":[{"value":"1708-5381","type":"print"},{"value":"1708-539X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]}}}