{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:13:59Z","timestamp":1777943639969,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Mechanisms of walking limitation in arterial claudication are incompletely elucidated. We aimed to identify new variables associated to walking limitation in patients with claudication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed data of 1120 patients referred for transcutaneous exercise oxygen pressure recordings (TcpO\n                      <jats:sub>2<\/jats:sub>\n                      ). The outcome measurement was the absolute walking time on treadmill (3.2 km\/h, 10% slope). We used both: linear regression analysis and a non-linear analysis, combining support vector machines and genetic explanatory in 800 patients with the following resting variables: age, gender, body mass index, the presence of diabetes, minimal ankle to brachial index at rest, usual walking speed over 10 m (usual-pace), number of comorbid conditions, active smoking, resting heart rate, pre-test glycaemia and hemoglobin, beta-blocker use, and exercise-derived variables: minimal value of pulse oximetry, resting chest-TcpO\n                      <jats:sub>2<\/jats:sub>\n                      , decrease in chest TcpO\n                      <jats:sub>2<\/jats:sub>\n                      during exercise, presence of buttock ischemia defined as a decrease from rest of oxygen pressure index \u226415\u2009mmHg. We tested the models over 320 other patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Independent variables associated to walking time, by decreasing importance in the models, were: age, ankle to brachial index, usual-pace; resting TcpO\n                      <jats:sub>2<\/jats:sub>\n                      , body mass index, smoking, buttock ischemia, heart rate and beta-blockers for the linear regression analysis, and were ankle to brachial index, age, body mass index, usual-pace, decrease in chest TcpO\n                      <jats:sub>2<\/jats:sub>\n                      , smoking, buttock ischemia, glycaemia, heart rate for the non-linear analysis. Testing of models over 320 new patients gave r\u2009=\u20090.509 for linear and 0.575 for non-linear analysis (both p\u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Buttock ischemia, heart rate and usual-pace are new variables associated to walking time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1708538118813708","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T21:53:28Z","timestamp":1542318808000},"page":"260-269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of new factors associated to walking impairment in patients with vascular-type claudication"],"prefix":"10.1177","volume":"27","author":[{"given":"Tinhinan","family":"Mezdad","sequence":"first","affiliation":[{"name":"Vascular Medicine, University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Henni","sequence":"additional","affiliation":[{"name":"Vascular Medicine, University Hospital, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Feuilloy","sequence":"additional","affiliation":[{"name":"ESEO-GSII, LUNAM Universit\u00e9, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Chauvet","sequence":"additional","affiliation":[{"name":"LARIS EA7315, LUNAM Universit\u00e9, Angers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Schang","sequence":"additional","affiliation":[{"name":"ESEO-GSII, LUNAM Universit\u00e9, Angers, 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