{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:46:06Z","timestamp":1779176766419,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T00:00:00Z","timestamp":1590192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the efficacy and reliability of infliximab treatment in Behcet\u2019s disease with vascular involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center retrospective study included a total of 18 patients diagnosed with Behcet\u2019s disease with vascular involvement who were initiated infliximab treatment after exhibiting resistance to conventional immunosuppressive treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventeen patients achieved remission with infliximab treatment. While 18 patients were receiving a median of 50 (IQR: 20\u201361) mg\/day equivalent of methylprednisolone before infliximab treatment, after infliximab treatment, only four patients were receiving 4\u2009mg\/day equivalent of methylprednisolone ( p\u2009&lt;\u20090.001). Only 4 patients were receiving oral anticoagulant treatment during infliximab treatment, and compared to the patients who were not receiving oral anticoagulants, there was no significant difference between the two groups according to occurrence of new vascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Infliximab seems to be an effective and reliable treatment in Behcet\u2019s disease with vascular involvement and may also allow reduced dosage or even the discontinuation of corticosteroids. The results of our study suggest that oral anticoagulant use is unnecessary in Behcet\u2019s disease with vascular involvement. However, further long-term randomized controlled studies are needed to investigate the length of infliximab regimen, whether or not it should be discontinued, and if so, whether or not immunosuppressants should be given as maintenance after discontinuation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1708538120927701","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T04:08:25Z","timestamp":1590206905000},"page":"829-833","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Infliximab treatment in refractory vascular Behcet\u2019s disease: A single-center experience"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1852-7981","authenticated-orcid":false,"given":"Demet Yal\u00e7\u0131n","family":"Kehribar","sequence":"first","affiliation":[{"name":"Ondokuz Mayis University Faculty of Medicine K\u00f6rfez Mahallesi Atakum Samsun, samsun 55139 Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metin","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Ondokuz Mayis Universitesi Tip Fakultesi Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,23]]},"reference":[{"key":"bibr1-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000458"},{"key":"bibr2-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew486"},{"key":"bibr3-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.08.010"},{"key":"bibr4-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200301000-00006"},{"key":"bibr5-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526.32.2.75"},{"key":"bibr6-1708538120927701","doi-asserted-by":"crossref","unstructured":"Silvestri E, Cenci C, Della Bella C, et\u00a0al. Cardiovascular issues: aneurysms and pseudoaneurysms, thrombosis, atherosclerosis, and cardiac involvement. In: Emmi L (ed)\n                      Beh\u00e7et's syndrome. Rare diseases of the immune system\n                      . Milano: Springer, 2014, pp.125\u2013135.","DOI":"10.1007\/978-88-470-5477-6_11"},{"key":"bibr7-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80250-1"},{"key":"bibr8-1708538120927701","first-page":"808","volume":"77","author":"Hatemi G","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"bibr9-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1002\/art.34450"},{"key":"bibr10-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu233"},{"key":"bibr11-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.08.004"},{"key":"bibr12-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2017.1328496"},{"key":"bibr13-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.09.002"},{"key":"bibr14-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003863"},{"key":"bibr15-1708538120927701","first-page":"1078","volume":"335","author":"Disease ISGfBs","year":"1990","journal-title":"Lancet"},{"key":"bibr16-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000494"},{"key":"bibr17-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13778"},{"key":"bibr18-1708538120927701","doi-asserted-by":"publisher","DOI":"10.1002\/art.40531"}],"container-title":["Vascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538120927701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1708538120927701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538120927701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:33:16Z","timestamp":1777707196000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1708538120927701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,23]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/1708538120927701"],"URL":"https:\/\/doi.org\/10.1177\/1708538120927701","relation":{},"ISSN":["1708-5381","1708-539X"],"issn-type":[{"value":"1708-5381","type":"print"},{"value":"1708-539X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,23]]}}}