{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:41:39Z","timestamp":1789051299136,"version":"build-2803163510"},"reference-count":79,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002767","name":"Hunan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2018JJ6097"],"award-info":[{"award-number":["2018JJ6097"]}],"id":[{"id":"10.13039\/501100002767","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Provincial Department of Education","award":["19K084 and 19C1722"],"award-info":[{"award-number":["19K084 and 19C1722"]}]},{"name":"Research Center of Diagnosis and Treatment Technology for Lipid Metabolism Disorders of Chenzhou, Hunan Province","award":["yfzx201907"],"award-info":[{"award-number":["yfzx201907"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202535"],"award-info":[{"award-number":["81202535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Bureau of Chenzhou, Hunan Province","award":["zdyf201925"],"award-info":[{"award-number":["zdyf201925"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) remains the primary cause of morbidity and mortality worldwide. The abnormal proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of CVD. The functional and phenotypic changes in vascular cells are mediated by complex signaling cascades that initiate and control genetic reprogramming. Many studies have demonstrated that signal transducer and activator of transcription 3 (STAT3) regulates a diverse array of functions relevant to atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this review, we summarize the studies on the STAT3-mediated proliferation of VSMCs and subsequent CVDs such as hypertension, atherosclerosis, stroke, coronary artery disease, and myocardial infarction. Furthermore, we describe the general background of STAT3, its structure, function and regulation as well as the STAT3 signaling pathway. Finally, we highlight some potential issues and propose some solutions to these issues. Results and conclusions: STAT3 activation promotes the proliferation of VSMCs by regulating the transcription of genes. Studying the mechanism of VSMC proliferation induced by the STAT3 pathway is valuable for finding therapeutic targets for CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1708538120929504","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T01:30:14Z","timestamp":1591147814000},"page":"821-828","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Role of the signal transducer and activator of transcription 3 protein in the proliferation of vascular smooth muscle cells"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7971-1360","authenticated-orcid":false,"given":"Hong-Xia","family":"Tang","sequence":"first","affiliation":[{"name":"The First People\u2019s Hospital of Chenzhou, Institute of Pharmacy and Pharmacology, University of South China, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Ping","family":"Qin","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Chenzhou, Institute of Pharmacy and Pharmacology, University of South China, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-6623","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Chenzhou, Institute of Pharmacy and Pharmacology, University of South China, Hunan, China"},{"name":"School of Pharmacy, Southern Medical University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"bibr1-1708538120929504","doi-asserted-by":"crossref","unstructured":"Gregory AR, Degu A, Kalkidan HA, et al. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.\n                      Lancet\n                      2018; 392: 1736\u20131788.","DOI":"10.1016\/S0140-6736(18)32203-7"},{"key":"bibr2-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1113\/JP271340"},{"key":"bibr3-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.3.487"},{"key":"bibr4-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2003"},{"key":"bibr5-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12466"},{"key":"bibr6-1708538120929504","doi-asserted-by":"publisher","DOI":"10.2174\/1566524015666150921105031"},{"key":"bibr7-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3818"},{"key":"bibr8-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv103"},{"key":"bibr9-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/nm1102-1249"},{"key":"bibr10-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.12.1501"},{"key":"bibr11-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.06.145"},{"key":"bibr12-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1211\/002235703765344487"},{"key":"bibr13-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/nrm909"},{"key":"bibr14-1708538120929504","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/S0092-8674(02)00701-8","volume":"109","author":"O\u2019Shea JJ, Gadina M and Schreiber RD","year":"2002","journal-title":"Cell"},{"key":"bibr15-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1039\/b606246f"},{"key":"bibr16-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.9.5307"},{"key":"bibr17-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/ni1052"},{"key":"bibr18-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005082200"},{"key":"bibr19-1708538120929504","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1158\/0008-5472.939.65.3","volume":"65","author":"Yang J, Chatterjee-Kishore M, Staugaitis SM","year":"2005","journal-title":"Cancer Res"},{"key":"bibr20-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3656"},{"key":"bibr21-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203551"},{"key":"bibr22-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.22.6670"},{"key":"bibr23-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0906-3"},{"key":"bibr24-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(98)90019-1"},{"key":"bibr25-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/hh1301.093615"},{"key":"bibr26-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.1.12"},{"key":"bibr27-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/nri2093"},{"key":"bibr28-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00497-X"},{"key":"bibr29-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.3.490"},{"key":"bibr30-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01271.2010"},{"key":"bibr31-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2875"},{"key":"bibr32-1708538120929504","doi-asserted-by":"crossref","unstructured":"Crowley SD, Gurley SB, Herrera MJet\u00a0al. \nAngiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.\n                      Proc Natl Acad Sci USA\n                      2006; \n103: 17985\u201317990.","DOI":"10.1073\/pnas.0605545103"},{"key":"bibr33-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.11.003"},{"key":"bibr34-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21866"},{"key":"bibr35-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.695346"},{"key":"bibr36-1708538120929504","first-page":"1021","volume":"7","author":"Zheng L, Jia X, Zhang C","year":"2015","journal-title":"Am J Transl Res"},{"key":"bibr37-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.470"},{"key":"bibr38-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062788"},{"key":"bibr39-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b18-00387"},{"key":"bibr40-1708538120929504","first-page":"2865","volume":"41","author":"Chen J","year":"2018","journal-title":"Int J Mol Med"},{"key":"bibr41-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.1999.010204.x"},{"key":"bibr42-1708538120929504","first-page":"995","volume":"275","author":"Jacobson PB, Kuchera SL, Metz A","year":"1995","journal-title":"J Pharmacol Exp Therapeut"},{"key":"bibr43-1708538120929504","first-page":"110","volume":"9","author":"Hsieh HL, Lin CC, Shih RH","year":"2012","journal-title":"J Neuroinflamm"},{"key":"bibr44-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000077407.90309.65"},{"key":"bibr45-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.12.016"},{"key":"bibr46-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.11.015"},{"key":"bibr47-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00092-5"},{"key":"bibr48-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00394.2006"},{"key":"bibr49-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00529.2007"},{"key":"bibr50-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13986"},{"key":"bibr51-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186245"},{"key":"bibr52-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/srep35302"},{"key":"bibr53-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.10.081"},{"key":"bibr54-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12265"},{"key":"bibr55-1708538120929504","first-page":"10375","volume":"8","author":"Li TJ, Chen YL, Gua CJ","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr56-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1159\/000079706"},{"key":"bibr57-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000261350.61711.9e"},{"key":"bibr58-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.8.1364"},{"key":"bibr59-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2007.07.001"},{"issue":"5","key":"bibr60-1708538120929504","first-page":"H1713","volume":"260","author":"Ikeda U IM","year":"1991","journal-title":"Am J Physiol"},{"key":"bibr61-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.04.016"},{"key":"bibr62-1708538120929504","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080163"},{"key":"bibr63-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1159\/000355193"},{"key":"bibr64-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.312470"},{"key":"bibr65-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/hc4701.099585"},{"key":"bibr66-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1038\/nature05162"},{"key":"bibr67-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.04.002"},{"key":"bibr68-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604569113"},{"key":"bibr69-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26839"},{"key":"bibr70-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42823"},{"key":"bibr71-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/hc3801.095663"},{"key":"bibr72-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.312186"},{"key":"bibr73-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp117"},{"key":"bibr74-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2006.04.009"},{"key":"bibr75-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2008.06.001"},{"key":"bibr76-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.06.021"},{"key":"bibr77-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.4.931"},{"key":"bibr78-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.6.3336"},{"key":"bibr79-1708538120929504","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.4.1996"}],"container-title":["Vascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538120929504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1708538120929504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1708538120929504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:33:17Z","timestamp":1777707197000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1708538120929504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,2]]},"references-count":79,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/1708538120929504"],"URL":"https:\/\/doi.org\/10.1177\/1708538120929504","relation":{},"ISSN":["1708-5381","1708-539X"],"issn-type":[{"value":"1708-5381","type":"print"},{"value":"1708-539X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,2]]}}}