{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:22:36Z","timestamp":1791386556938,"version":"4.3.3"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"This study was supported by an unrestricted grant from Acotec Scientific."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Femoropopliteal chronic total occlusions are challenging to treat, and evidence of the effectiveness of drug-coated balloon angioplasty for long femoropopliteal chronic total occlusion lesions is limited. We compared the midterm outcomes of drug-coated balloon angioplasty versus plain old balloon angioplasty (POBA) for femoropopliteal chronic total occlusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 95 patients from the AcoArt I trial (ClinicalTrials.gov identifier NCT01850056) with \u22655-cm femoropopliteal chronic total occlusion lesions were enrolled in this post-hoc subset analysis (drug-coated balloon, n\u2009=\u200950; POBA, n\u2009=\u200945). The primary endpoints were primary patency and clinically driven target lesion revascularization (CD-TLR) at 24\u2009months. The secondary endpoints were late lumen loss at six\u2009months and binary restenosis, major adverse events (composite of death and target limb amputation), change in the Rutherford class, and the ankle-brachial index at 24\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Demographic, clinical, and lesion characteristics were matched (mean lesion length, 20\u2009cm). The six-month late-lumen loss rate was lower in the drug-coated balloon than POBA group (0.18\u2009\u00b1\u20090.81 vs. 1.34\u2009\u00b1\u20090.94\u2009mm, respectively; P\u2009&lt;\u20090.001). The 24-month primary patency rate was significantly higher in the drug-coated balloon than POBA group (53.85% vs. 17.50%, respectively; P\u2009&lt;\u20090.001). The CD-TLR rate in the drug-coated balloon and POBA groups was 12.77 and 45.24%, respectively ( P\u2009=\u20090.002). The 24-month overall mortality rate in the drug-coated balloon and POBA groups was 12.77% and 6.98%, respectively ( P\u2009=\u20090.360), with no device- or procedure-related deaths. One major amputation had occurred in each group by the 24-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The paclitaxel drug-coated balloon shows better primary patency and freedom from target lesion revascularization than POBA at 24month after treatment of femoropopliteal chronic total occlusions (\u22655\u2009cm) lesion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1708538120953663","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T15:04:33Z","timestamp":1599663873000},"page":"340-349","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of drug-coated balloon angioplasty versus uncoated balloon angioplasty in treatment of total occlusions with severe femoropopliteal lesions: An additional analysis from the AcoArt I study"],"prefix":"10.1177","volume":"29","author":[{"given":"Guoyi","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senhao","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baixi","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Peripheral Vascular Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The People\u2019s Hospital of Liaoning Province, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy, The First Affiliated Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingfan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-8390","authenticated-orcid":false,"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the AcoArt I Trial 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