{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:15:37Z","timestamp":1777943737030,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shandong Provincial Medical Science and Technology Development Programme Foundation","award":["2017WS462"],"award-info":[{"award-number":["2017WS462"]}]},{"name":"Technology Programme Foundation of Jinan","award":["201821007"],"award-info":[{"award-number":["201821007"]}]},{"name":"Shandong Provincial Key Research and Development Programme Foundation","award":["2018GSF118009"],"award-info":[{"award-number":["2018GSF118009"]}]},{"name":"Jinan City Medical and Health Development Plan","award":["2018-2-31"],"award-info":[{"award-number":["2018-2-31"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension associated with hyperhomocysteinemia (HHcy) is correlated with a high risk of vascular diseases. Studies found that folic acid (FA) supplementation can reduce the risk of cardiovascular and cerebrovascular events. The aim of the present study was to explore the potential mechanisms of FA attenuating HHcy-related arterial injury in spontaneously hypertensive rats (SHRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>24 SHRs were randomized into the control group, the HHcy group, and the HHcy + FA group (8 per group). The SHRs in the HHcy group and the HHcy + FA group were given DL-Hcy intraperitoneally to mimic hypertension associated with HHcy. The SHRs in the HHcy + FA group were given FA by gavage to mimic an FA-fortified diet. The histopathology and immunohistochemistry of rat aorta and carotid artery were analyzed, and the relative expression levels of immune\/inflammation and oxidative stress molecules in arterial tissue were detected by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FA significantly reduced the expression levels of nuclear factor-\u03ba-gene binding (NF-\u03baB) p65\/Rela and interleukin-6 (IL-6) in rat arterial tissues, as well as the levels of plasma HHcy and serum malondialdehyde (MDA) in hypertension associated with HHcy rats ( p &lt; 0.05). At the same time, FA significantly increased the serum superoxide dismutase (SOD) level in hypertension associated with HHcy rats, and even the SOD level of the HHcy + FA group was higher than that of the control group ( p &lt; 0.05). However, HHcy induced the opposite results of the above indicators in SHRs compared with the control group ( p &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The arterial protection mechanisms of FA are related to reducing the concentration of HHcy to eliminate the tissue toxicity of HHcy, inhibiting NF-\u03baBp65\/Rela\/IL-6 pathway molecules to regulate inflammatory response, and promoting the potential anti-oxidative stress pathway molecules to reduce oxidative stress level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17085381211036549","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T22:08:13Z","timestamp":1628287693000},"page":"988-998","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The protective mechanism of folic acid on hyperhomocysteinemia-related arterial injury in spontaneously hypertensive rats: Folic acid against arterial inflammation"],"prefix":"10.1177","volume":"30","author":[{"given":"Lihua","family":"Zhang","sequence":"first","affiliation":[{"name":"Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"},{"name":"Department of Medicine, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Women Healthcare, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changcheng","family":"Xing","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoshan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6212-707X","authenticated-orcid":false,"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China"},{"name":"Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"bibr1-17085381211036549","first-page":"976","volume":"47","author":"Hu DY","year":"2009","journal-title":"Chin J Intern Med"},{"key":"bibr2-17085381211036549","first-page":"614","volume":"17","author":"Jian-Ping LI","year":"2007","journal-title":"J Peking Univ"},{"key":"bibr3-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.08.016"},{"key":"bibr4-17085381211036549","first-page":"1502","volume":"21","author":"Zhao Q","year":"2020","journal-title":"Nutr Res"},{"key":"bibr5-17085381211036549","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071957"},{"key":"bibr6-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313268200"},{"key":"bibr7-17085381211036549","first-page":"1600","volume":"20","author":"Perla\u2010Kajan J","year":"2016","journal-title":"FASEB J"},{"key":"bibr8-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-205757"},{"key":"bibr9-17085381211036549","first-page":"657","volume":"39","author":"Yideng J","year":"2010","journal-title":"Acta Biochim Biophys Sinica"},{"key":"bibr10-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20153101012"},{"key":"bibr11-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1009-2"},{"key":"bibr12-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2005"},{"key":"bibr13-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-008-0619-Y"},{"key":"bibr14-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14965-x"},{"key":"bibr15-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.66"},{"key":"bibr16-17085381211036549","first-page":"175","volume":"18","author":"Yan HZ","year":"2017","journal-title":"Exp Ther Med"},{"key":"bibr17-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80558-9"},{"key":"bibr18-17085381211036549","first-page":"1001","volume":"10","author":"Kumasaka T","year":"1996","journal-title":"J Clin Invest"},{"key":"bibr19-17085381211036549","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.13.9367351"},{"key":"bibr20-17085381211036549","unstructured":"Mutavdzin S, Gopcevic K, Stankovic S, et al. 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