{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T08:42:41Z","timestamp":1792744961794,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to evaluate the outcomes of endovascular treatment in patients with moderate and severe claudication due to femoropopliteal disease, that is, disease of the superficial femoral and popliteal arteries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of all patients with moderate and severe claudication (Rutherford 2 and 3) undergoing endovascular treatment for FP disease between January 2012 and December 2017 at two university-affiliated hospitals was performed. All procedures were performed by vascular surgeons. Primary outcomes were mortality, freedom from reintervention, major adverse limb events defined as major amputations, open surgical revascularization, or progression to chronic limb-threatening ischemia (CLTI) at 30\u00a0days, 1\u00a0year, 2\u00a0years, and last follow-up. Unadjusted odds ratios were calculated to identify variables associated with adverse outcomes, and Kaplan\u2013Meier survival curves were used to determine mortality and freedom from reintervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty-five limbs in 74 patients were identified on review. Mean age was 69.6 \u00b1 9.8\u00a0years and 74.3% were males. At a median follow-up of 49.0 \u00b1 25.5\u00a0months, all-cause mortality rate was 8.1% (6 patients) with 16.7% being due to cardiovascular causes. Reintervention rates were 1.2%, 16.5%, and 21.2% at 30\u00a0days, 1\u00a0year, and 2\u00a0years, respectively. Major adverse limb events occurred in 3 patients and rates were 0%, 1.2%, and 2.4% at 30\u00a0days, 1\u00a0year, and 2\u00a0years, respectively. Progression to CLTI was 0%, 1.2%, and 1.2% at 30\u00a0days, 1\u00a0year, and 2\u00a0years, respectively. Claudication had improved or resolved in 55.6% ( n = 34 patients), stable in 38.9% ( n = 21 patients), and worse in 5.6% ( n = 3 patients) Age \u2265 70\u00a0years (OR = 4.09 (1.14\u201314.66), p = 0.027), TASCII A lesion (OR = 4.67 (1.14\u201319.17), p = 0.025), and presence of 3-vessel runoff (OR = 3.70 (1.18\u201311.59), p = 0.022) predicted symptoms\u2019 improvement. TASCII A lesions were less likely to require reintervention (OR = 0.23 (0.06\u20130.86), p = 0.020). Reintervention within 1\u00a0year (OR = 11.67 (0.98\u2013138.94), p = 0.017), reintervention with a stent (OR = 14.40 (1.19\u2013173.67), p = 0.008) and more than one reintervention (OR = 39.00 (2.89\u2013526.28), p &lt; 0.001) predicted major adverse limb events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Careful patient selection is important when planning endovascular treatment in patients with intermittent claudication and FP disease. This could result in symptomatic improvement in more than half of the patients. Adverse outcomes such as major adverse limb events, progression to CLTI, and amputations occur at low rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17085381211039668","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T05:57:55Z","timestamp":1629093475000},"page":"882-890","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of endovascular treatment of patients with intermittent claudication due to femoropopliteal disease"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4544-0582","authenticated-orcid":false,"given":"Ahmed A","family":"Naiem","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert James","family":"Doonan","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren K","family":"Steinmetz","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent S","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Girsowicz","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Jewish General Hospital, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P","family":"Bayne","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Jewish General Hospital, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I","family":"Obrand","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Jewish General Hospital, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather L","family":"Gill","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"bibr1-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"bibr2-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174526"},{"key":"bibr3-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.063"},{"key":"bibr4-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu080"},{"key":"bibr5-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000366"},{"key":"bibr6-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.12.009"},{"key":"bibr7-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.09.009"},{"key":"bibr8-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2003.09.012"},{"key":"bibr9-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2001.1413"},{"key":"bibr10-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000612"},{"key":"bibr11-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.01.027"},{"key":"bibr12-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0077"},{"key":"bibr13-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1583\/13-4618R.1"},{"key":"bibr14-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-1147"},{"key":"bibr15-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10765"},{"key":"bibr16-17085381211039668","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530120067043"},{"key":"bibr17-17085381211039668","first-page":"CD000990","volume":"2","author":"Leng 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