{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:16:08Z","timestamp":1777943768421,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"\u0130zmir Katip \u00c7elebi University Scientific Research Projects Unit","award":["2018-\u00d6NAP-TIPF-0005"],"award-info":[{"award-number":["2018-\u00d6NAP-TIPF-0005"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In addition to the hemostatic properties of hemostatic agents, the investigation of their immunogenic properties, their local effects on application area has been the subject of many experimental studies. There are limited data on the inflammatory effects of Bovine serum albumin-glutaraldehyde and Polyethylene glycol polymer. Therefore, we investigated the effects of these agents on tissue reactions and inflammation in rabbit carotid artery anastomosis in our experimental study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-one New Zealand male rabbits were randomly divided into three groups. The right carotid artery anastomosis was performed on the control group after transection. Hemostatic agents were applied locally to other two groups separately after transection and anastomosis. At the end of 28\u00a0days, the type of inflammation, inflammatory cell infiltration, degree of inflammation, and amount of residual adhesives were examined and compared statistically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cell infiltrations associated with inflammation on the anastomosis site (eosinophils, epithelioid\/giant cells, lymphocytes, and plasma cells) and inflammation grade in the groups of hemostatic agents were significantly lower compared to the control group ( p &lt; .05). There was no difference between the hemostatic agents. While mild inflammation (61.9%) was dominant in the groups of hemostatic agents, moderate inflammation (85.7%) was more common in the control group. No severe inflammation was observed in any of the three groups. Residual sealant grade between hemostatic agents did not differ significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When inflammation and tissue reactions of the 4th week were evaluated, it was determined that both hemostatic agents did not cause severe inflammation. However, comparative results at multiple time intervals are needed due to the dynamic process of inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17085381221075484","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T07:38:27Z","timestamp":1646033907000},"page":"554-563","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of bovine serum albumin-glutaraldehyde and polyethylene glycol polymer on local tissue reaction and inflammation in rabbit carotid artery anastomosis"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-5155","authenticated-orcid":false,"given":"Yuksel","family":"Besir","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Izmir Katip \u00c7elebi University Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4935-0816","authenticated-orcid":false,"given":"Erturk","family":"Karaagac","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Mu\u015f State Hospital, Mu\u015f, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2455-9605","authenticated-orcid":false,"given":"Meltem","family":"Kurus","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Izmir Katip \u00c7elebi University Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1793-7719","authenticated-orcid":false,"given":"Erdi","family":"Keselik","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Izmir Katip \u00c7elebi University Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1015-5260","authenticated-orcid":false,"given":"Sahin","family":"Iscan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Izmir Katip \u00c7elebi University Atat\u00fcrk Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-8808","authenticated-orcid":false,"given":"Orhan","family":"Gokalp","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Izmir Katip \u00c7elebi University Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4684-0860","authenticated-orcid":false,"given":"Bortecin","family":"Eygi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Izmir Katip \u00c7elebi University Atat\u00fcrk Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-9448","authenticated-orcid":false,"given":"Hasan","family":"Iner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Izmir Katip \u00c7elebi University Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1756-0402","authenticated-orcid":false,"given":"Nihan","family":"Yesilkaya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Izmir Katip \u00c7elebi University Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1459-7939","authenticated-orcid":false,"given":"Barcin","family":"Ozcem","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Near East University Faculty of Medicine, Lefkosa, 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