{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:17:04Z","timestamp":1777943824517,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Results from the BIOLUX P-III registry have demonstrated favourable outcomes of Passeo-18 Lux\u2122 (Biotronik\u00ae, Buelach, Switzerland) drug-coated balloon in treating obstructive infrainguinal peripheral artery disease, but it has not been established if Asians would benefit to the same extent as non-Asians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A subgroup analysis was performed on the 24-month data comparing the Asian cohort (AC) to non-Asian cohort (NAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AC included 49 patients with 77 lesions. AC was significantly younger (65.6 vs 70.3\u00a0years, p &lt; 0.05), had more diabetes (87.8% vs 45.3%, p &lt; 0.05), and was more likely to present with CLTI (73.5% vs 35.3%, p &lt; 0.001) compared to NAC. They had significantly longer mean target lesions (115 vs 86.9\u00a0mm, p = 0.006), and received significantly higher paclitaxel doses (10.7 vs 7.2\u00a0mg, p = 0.0005). Device, technical and procedural successes were 125\/125(100%), 95\/97(97.5%) and 45\/49(91.8%), respectively. There was no significant difference in target lesion revascularization rates between groups (10.5% vs 12%, p = 0.91). However, the AC had more major adverse events (30.2% vs 16.1%, p = 0.001), amputations (26.3% vs 6.2%, p &lt; 0.05) and mortality (37.9% vs 10.6%, p &lt; 0.05) at 24 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Passeo-18 Lux\u2122 use was efficacious in Asians, but was associated with higher adverse events, amputations and mortality rates, likely attributable to poorer patient comorbidities and more extensive PAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17085381221081969","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T21:20:31Z","timestamp":1649712031000},"page":"767-776","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Utility of paclitaxel-coated balloons for the treatment of infrainguinal disease in the Asian population \u2013 24-month outcome data from the BIOLUX P-III Global Registry 24-month Asian outcomes of BIOLUX P-III"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-4178","authenticated-orcid":false,"given":"Yun Le","family":"Linn","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Singapore General Hospital, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John CC","family":"Wang","sequence":"additional","affiliation":[{"name":"Advanced Vascular & Endovascular Clinic, Mount Elizabeth Medical Centre, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uei","family":"Pua","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaiful AB","family":"Yahaya","sequence":"additional","affiliation":[{"name":"Institute Jantung Negara, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward TC","family":"Choke","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sengkang General Hospital, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-Tec","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Singapore General Hospital, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Brodmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Angiology, Medical University, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjun-Yip","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Singapore General Hospital, Singapore, Singapore"},{"name":"Duke NUS Graduate Medical School, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"bibr1-17085381221081969","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.05.006"},{"key":"bibr2-17085381221081969","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"bibr3-17085381221081969","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv006"},{"key":"bibr4-17085381221081969","doi-asserted-by":"publisher","DOI":"10.23736\/S0021-9509.19.11115-9"},{"issue":"3","key":"bibr5-17085381221081969","first-page":"213","volume":"26","author":"Braga SF","year":"2019","journal-title":"Rev Port Cir Cardiotorac 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