{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:17:30Z","timestamp":1777943850260,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thromboangiitis Obliterans (TAO) is a disease of small and medium-sized arteries with an unclear natural course. This study aims to establish a national registry of the disease to gain a better understanding of its epidemiology and clinical course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This study was a cohort study of 242 patients with a high probability of TAO admitted to Mashhad University of Medical Sciences (MUMS) hospitals from 2000 to 2015. Of these, 91 patients with a confirmed diagnosis were included in the study (90 males and 1 female) with a mean age of 35 \u00b1 7.8\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The most common symptom upon onset of the disease was paresthesia (29.7%), followed by cold sensitivity and paresthesia (93.4%) during the progression of the disease and Raynaud syndrome or vasospasm (93.9%) in the active phase. The right lower limb was the most commonly affected limb (46.2%), and presenting ischemic symptoms in 48.4%.<\/jats:p>\n                    <jats:p>\n                      Statistics indicated a positive correlation between the duration of Burger\u2019s disease and the number of affected limbs (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.001). There was no effect of disease duration on the likelihood of amputations (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.28).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Some patients may experience mild, subtle symptoms for years before the initial signs and symptoms appear, which can be severe and rapidly progress to the point of requiring amputation.<\/jats:p>\n                    <jats:p>We suggest that the diagnostic criteria for Buerger\u2019s disease should be revised in light of the presence of atherosclerosis and its associated risk factors, which present a challenge in terms of diagnosis and treatment. Clinical experience will be of great importance in this regard.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17085381231175257","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T13:40:36Z","timestamp":1683898836000},"page":"1150-1158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A comprehensive review of the epidemiology and clinical features of 91 cases with Buerger\u2019s disease"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2724-7463","authenticated-orcid":false,"given":"Mohammad Hadi Saeed","family":"Modaghegh","sequence":"first","affiliation":[{"name":"Mashhad University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Mahdi","family":"Kamyar","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Shafiei","sequence":"additional","affiliation":[{"name":"Qom University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh Sadat","family":"Shariatmaghani","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Saremi","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Sadeghipour Kermani","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1024\/0301-1526\/a000371"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2013.04.003"},{"key":"e_1_3_4_4_2","unstructured":"Cronenwett JL Johnston KW. 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