{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:17:34Z","timestamp":1777943854273,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to determine the incidence, clinical and paraclinical characteristics and outcomes of Covid-19 positive patients presenting in the Emergency Department (ED) with and treated for acute limb ischaemia (ALI) during a 2-year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study was conducted in the ED of St. Spiridon County Clinical Emergency Hospital in Iasi, north-east region of Romania. The patients included in this study presented in the ED between March 1\n                      <jats:sup>st<\/jats:sup>\n                      , 2020 and February 28\n                      <jats:sup>th<\/jats:sup>\n                      , 2022 with ALI and Covid-19.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, a total number of 141018 patients were evaluated in our ED, 8578 (representing 6,08%) patients being diagnosed with Covid-19. Of them, 98 (1.14% of all with Covid-19) presented ALI. The mean age was 70.9 \u00b1 10.23 and 67.3% of the patients were males. At admission, 57% of patients had Covid-19-related pneumonia, identified on X-ray or CT scan. Of all patients, 81 (82%) were diagnosed with ALI in lower limbs with 10% of them having affected both limbs. 95% of the patients presented comorbidities, the main being cardiac (85%), diabetes mellitus (37%), vascular (24%) and neurological (22.6%). Non-survivor patients were more likely to have Covid-19 pneumonia on chest X-ray or CT scan, 92% versus 44% (OR 15, CI 3.3; 68, p &lt; .01), lymphopenia 96% versus 70% (OR 10.2, CI 1.30; 80.9, p &lt; .01), a NLR over 9.77% versus 30% (OR 7.5, CI 2.6; 21.4, p &lt; .01), acidosis 65% versus 33% (OR 3.8, CI 1.4; 9.7, p &lt; .01), abnormal AST, 69% versus 29% (OR 5.4, CI 2; 14.5, p &lt; .01) and secondary amputation, 38.5 versus 11.1% (OR 5, CI 1.7; 14.7, p &lt; 0.1). Overall, the mortality rate was 26.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of ALI in patients infected with Covid-19 who were evaluated in our ED was 1.14%. The highest mortality rate was probably related to Covid-19 pneumonia. We observed that patients with Covid-19 pneumonia, lymphopenia, a NLR &gt;9, metabolic acidosis, increased AST at ED admission and secondary amputation had a higher mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17085381241236932","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T20:10:15Z","timestamp":1709151015000},"page":"50-57","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology, clinical features and prognostic factors in patients with Covid-19 and acute limb ischaemia \u2013 A single center study"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5207-8529","authenticated-orcid":false,"given":"Irina","family":"Ciumanghel","sequence":"first","affiliation":[{"name":"University of Medicine and Pharmacy \u201eGr. T. Popa\u201d, Iasi, Romania"},{"name":"Emergency Department, Clinical Emergency County Hospital \u201eSt. Spiridon\u201d, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulian","family":"Buzincu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201eGr. T. Popa\u201d, Iasi, Romania"},{"name":"Anesthesiology and Intensive Care Department, Clinical Emergency County Hospital \u201eSt. Spiridon\u201d, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi Ionut","family":"Ciumanghel","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201eGr. T. Popa\u201d, Iasi, Romania"},{"name":"Anesthesiology and Intensive Care Department, Clinical Emergency County Hospital \u201eSt. Spiridon\u201d, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza","family":"Barbuta","sequence":"additional","affiliation":[{"name":"Emergency Department, Clinical Emergency County Hospital \u201eSt. Spiridon\u201d, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Cimpoesu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201eGr. T. Popa\u201d, Iasi, Romania"},{"name":"Emergency Department, Clinical Emergency County Hospital \u201eSt. Spiridon\u201d, Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"bibr1-17085381241236932","unstructured":"Available online: https:\/\/covid19.who.int (accessed 21 February 2023)."},{"key":"bibr2-17085381241236932","doi-asserted-by":"publisher","DOI":"10.1177\/20587384211048026"},{"key":"bibr3-17085381241236932","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.09.006"},{"key":"bibr4-17085381241236932","unstructured":"Bell D, Murphy A, Radiological society of North America. 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