{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:49:38Z","timestamp":1792615778579,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Predictive value of systemic immune-inflammation index (SII) has been shown in clinical outcomes and complexity of coronary artery disease, acute coronary syndrome, and heart failure. We sight to evaluate value of SII in patients with lower extremity arterial disease (LEAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 271 patients diagnosed with LEAD were included to our study. Blood samples of the patients were collected and analyzed for biochemical variables and complete blood count parameters. SII value of each patient was calculated. The complexity of atherosclerotic disease was classified according to Trans-Atlantic Inter-Society Consensus (TASC II) classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with TASC C-D were older than patients in TASC A-B group (63.06 \u00b1 9.24\u00a0years and 60.85 \u00b1 8.75\u00a0years, respectively). Other co-morbidities were comparable in both groups. Hemoglobin level and lymphocyte count were significantly lower, neutrophil, platelet counts, and SII values were significantly higher in patients with TASC C-D disease compared to that of patients with TASC A-B disease. SII showed significant correlation with the severity of LEAD (r = 0.363,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). SII value of 664.24 predicted TASC C-D disease with a sensitivity and specificity of 60.8% and 73.3%, respectively. Results of multivariate logistic regression analysis showed that SII had higher odds ratio compared to platelet, neutrophil, and lymphocyte counts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher SII may indicate probability of more complex LEAD. This relationship seems plausible in terms of similar pathophysiology of coronary artery disease and peripheral artery disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17085381241251772","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T21:23:12Z","timestamp":1714944192000},"page":"797-803","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of systemic immune-inflammation index for predicting severity of lower extremity arterial disease"],"prefix":"10.1177","volume":"32","author":[{"given":"Ersan","family":"Oflar","sequence":"first","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evliya","family":"Akdeniz","sequence":"additional","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-3206","authenticated-orcid":false,"given":"Cennet","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fc\u015fra","family":"Mavi","sequence":"additional","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilay","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Nihan Turhan","family":"\u00c7a\u011flar","sequence":"additional","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-4439","authenticated-orcid":false,"given":"Ali Aycan","family":"Kavala","sequence":"additional","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2165-6853","authenticated-orcid":false,"given":"Sayg\u0131n","family":"T\u00fcrky\u0131lmaz","sequence":"additional","affiliation":[{"name":"Bak\u0131rkoy Dr Sadi Konuk Training and Research Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487312452968"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8295054"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0678-6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr043"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.5.425"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.513085"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.09.009"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2016.1165091"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319715577529"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.01.013"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319720987743"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211016274"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13230"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.919802"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.753133"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2021.12.011"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179705"},{"issue":"3","key":"e_1_3_3_19_2","first-page":"5","article-title":"Risk factors for atherosclerotic disease: present and future","volume":"3","author":"Vinereanu D","year":"2006","unstructured":"Vinereanu D. 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