{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:18:02Z","timestamp":1777943882464,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n Objective<\/jats:title>\n The determination of clinico-surgical predictors of carotid body tumour (CBT) metastasizing and\/or recurrence.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients with CBT but without a history of its previous treatment who had received inpatient medical aid at a tertiary surgical centre during the period 2011\u20132021 were retrospectively reviewed to obtain baseline data. Primary endpoints of the study were CBT metastasizing and\/or local recurrence after radical surgery (composite endpoint) and overall survival. Secondary endpoint of the study was primary patency of carotid arteries that had been repaired\/reconstructed as a result of CBT removal. Suspected predictors of CBT metastasizing\/recurrence were young age of CBT onset, positive family history, multifocal paraganglioma, Shamblin type III CBT, carotid bifurcation and\/or internal carotid artery (ICA) reconstruction as a result of CBT excision. To detect CBT metastasizing\/recurrence, prospective imaging-based whole-body screening was suggested to patients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fifty-three patients met the eligibility criteria. The overall survival rate was 100% at a median follow-up time of 68 months (interquartile range [IQR] 27\u2012104.5 months). The primary patency of repaired carotid arteries (\n n<\/jats:italic>\n = 9) was 88.9% at a median follow-up time of 99 months (IQR 15.5\u2012116.5 months). Thirty-nine patients underwent the prospective whole-body screening. Eight (20.5%) patients were diagnosed with metastatic disease (\n n<\/jats:italic>\n = 6) or local recurrence (\n n<\/jats:italic>\n = 2). Patients with CBT metastasizing\/recurrence were younger at age of CBT onset (\n p<\/jats:italic>\n = .011), more frequently had Shamblin type III CBT (\n p<\/jats:italic>\n = .004) and the necessity for carotid artery repair\/reconstruction (\n p<\/jats:italic>\n = .041) than patients without metastasizing\/recurrence. These two groups were similar in terms of gender (\n p<\/jats:italic>\n = .682), the prevalence of multifocal paraganglioma (\n p<\/jats:italic>\n = .167) and positive family history (\n p<\/jats:italic>\n = .180). Only the belonging of a CBT to Shamblin type III was defined as a statistically significant predictor of CBT metastasizing\/recurrence in both univariable and multivariable binary logistic regression analyses (odds ratio 30; 95% confidence interval: 2.649\u2013339.739;\n p<\/jats:italic>\n = .006 and odds ratio 75.409; 95% confidence interval: 1.082\u20135254.557;\n p<\/jats:italic>\n = .046, respectively). Multifocal paraganglioma as a predictor exhibited a strong tendency towards statistical significance (\n p<\/jats:italic>\n = .09 and\n p<\/jats:italic>\n = .072, respectively). Other suspected predictors didn\u2019t reach the level of statistical significance either in univariable (\n p<\/jats:italic>\n = .151 for positive family history) or in multivariable (\n p<\/jats:italic>\n = .211 for age of CBT onset;\n p<\/jats:italic>\n = .734 for carotid artery reconstruction\/repair) binary logistic regression analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Shamblin type III CBT has high potential for metastasizing and recurrence. Patients with Shamblin type III CBT and\/or multifocal paraganglioma should be considered for genetic testing as well as preoperative whole-body radiological imaging and long-term postoperative whole-body imaging-based follow-up.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/17085381241297067","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T22:15:09Z","timestamp":1730499309000},"page":"1424-1431","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term results of carotid body tumours surgery and predictive analytics on metastatic disease and recurrence"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-9758","authenticated-orcid":false,"given":"Najibullah I","family":"Verdikhanov","sequence":"first","affiliation":[{"name":", A.V. Vishnevsky National Medical Research Center of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey V","family":"Chupin","sequence":"additional","affiliation":[{"name":", A.V. Vishnevsky National Medical Research Center of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina E","family":"Timina","sequence":"additional","affiliation":[{"name":", A.V. Vishnevsky National Medical Research Center of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaurbek A","family":"Adyrkhaev","sequence":"additional","affiliation":[{"name":", A.V. Vishnevsky National Medical Research Center of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.03.010"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.12.097"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05740-x"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10252"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09704-6"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.05.031"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820902702"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-2-23"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-006-9093-0"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.01.015"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2013.05.003"}],"container-title":["Vascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17085381241297067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17085381241297067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17085381241297067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:40:37Z","timestamp":1777707637000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17085381241297067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/17085381241297067"],"URL":"https:\/\/doi.org\/10.1177\/17085381241297067","relation":{},"ISSN":["1708-5381","1708-539X"],"issn-type":[{"value":"1708-5381","type":"print"},{"value":"1708-539X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]}}}