{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:08:53Z","timestamp":1793711333340,"version":"4.6.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Vascular"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Peripheral artery disease (PAD) poses a growing clinical challenge due to an aging population, despite advances in treatment methods. Various scoring systems have emerged to predict high-risk patients, including the HALP (hemoglobin, albumin, lymphocyte, and platelet) score, known for predicting prognosis in cancers and stroke. This study assesses the HALP score\u2019s relation to lesion severity and long-term mortality in PAD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 305 symptomatic PAD patients undergoing endovascular intervention. The following formula was used to calculate the HALP score: hemoglobin (g\/L) \u00d7 albumin (g\/L) \u00d7 lymphocyte count (\/L) \/ platelet count (\/L). Lesion severity was classified by TASC-II: TASC AB and TASC CD. Mortality data were obtained from hospital and social security records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study involved 305 patients (mean age 64.4 \u00b1 11.8 years; 72.1% male), divided into survivors (208) and non-survivors (97). ROC analysis identified HALP score as the strongest predictor of long-term mortality (AUC: 0.736; 95% CI: 0.679\u20130.793;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001). HALP score (HR, 0.087; 95% CI, 0.025\u20131.300;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001), age (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001), DM (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .007), and CRP (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .013) independently predicted mortality. Kaplan\u2013Meier analysis showed higher HALP scores linked to lower long-term mortality (Log-rank: 20.102,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001), with an average follow-up of 48 \u00b1 18 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The HALP score emerged as a robust predictor of PAD prognosis, surpassing individual components and other parameters. Lower HALP scores correlated with more severe lesions and reduced life expectancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17085381251327000","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T03:56:12Z","timestamp":1741838172000},"page":"223-231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessing the prognostic value of HALP score in peripheral artery disease: Correlation with lesion severity and long-term mortality"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3780-7137","authenticated-orcid":false,"given":"Ali","family":"Evsen","sequence":"first","affiliation":[{"name":"Da\u011fkap\u0131 State Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-9784","authenticated-orcid":false,"given":"Adem","family":"Aktan","sequence":"additional","affiliation":[{"name":"Mardin Artuklu University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-4948","authenticated-orcid":false,"given":"Raif","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"\u00c7ermik State Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-5831","authenticated-orcid":false,"given":"Abdulaziz","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Dicle University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-6190","authenticated-orcid":false,"given":"Mehmet","family":"\u00d6zbek","sequence":"additional","affiliation":[{"name":"Dicle University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.73.Suppl_4.S8"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303504"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.27210"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.610318"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.01.008"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-016-9540-0"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2021.04.037"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/17085381231193494"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011245"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5175607"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400607"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0894-0959.2004.17603.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.05.012"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003019"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.051"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1708538114522227"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-03-0192"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.04.045"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574420951315"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.097"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056745"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2014.02.019"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319714535970"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.01.021"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.117"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081745"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2022.03.045"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.05.049"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.01.021"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i8.828"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000001271"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5629"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.02.027"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12271"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19146-y"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0333-8"}],"container-title":["Vascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17085381251327000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17085381251327000","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17085381251327000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:41:06Z","timestamp":1777707666000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17085381251327000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,13]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/17085381251327000"],"URL":"https:\/\/doi.org\/10.1177\/17085381251327000","relation":{},"ISSN":["1708-5381","1708-539X"],"issn-type":[{"value":"1708-5381","type":"print"},{"value":"1708-539X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,13]]}}}