{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:21:12Z","timestamp":1777555272435,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Anti-interleukin-13 antibody lebrikizumab is highly effective and tolerable for atopic dermatitis (AD). However, real-world data are limited on its effectiveness for different anatomical sites and clinical signs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To evaluate the effectiveness of lebrikizumab on different anatomical sites and clinical signs of AD.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    This study included 162 patients with moderate-to-severe AD who received lebrikizumab for 36 weeks. Eczema Area and Severity Index (EASI) was assessed at weeks 0, 4, 12, 24, and 36 on four anatomical sites (head\/neck, trunk, upper limbs, and lower limbs) and four clinical signs (erythema, edema\/papulation, excoriation, and lichenification).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Lebrikizumab consistently decreased EASI on all anatomical sites and all clinical signs through 36 weeks. Week 36 achievement rates of EASI 100 on the trunk and upper limbs (46.3% and 48.8%) were higher compared to head\/neck and lower limbs (28.9% and 33.3%), respectively. The percentage reduction of EASI and achievement rates of EASI 75 and EASI 100 at each time-point were highest for excoriation among clinical signs; week 36 achievement rates of EASI 100 for erythema, edema\/papulation, excoriation, and lichenification were 35.3%, 38.2%, 60.6%, and 37.1%, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Lebrikizumab consistently improves eruptions across all anatomical sites and clinical signs in AD throughout 36 weeks.\n                  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