{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:26:26Z","timestamp":1793568386560,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Atopic dermatitis (AD) affecting the head and neck (H&amp;N) area poses a clinical challenge due to the unique anatomical and physiological features of this region. Despite its well-documented impact on quality of life (QoL), evidence on the effectiveness of tralokinumab in treating AD specifically in the H&amp;N area remains limited.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To assess the clinical outcomes of tralokinumab in AD patients with H&amp;N involvement, informing clinical decision-making and improving patient care.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    A multicenter, retrospective cohort study across 5 Italian tertiary referral hospitals. Patients were stratified by H&amp;N involvement, and treatment outcomes were assessed using the Eczema Area and Severity Index (EASI), EASI H&amp;N, Investigator Global Assessment (IGA), Numerical Rating Scale (NRS) pruritus, NRS sleep, Dermatology Life Quality Index, Patient-Oriented Eczema Measure, and Atopic Dermatitis Control Tool.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Among 211 patients, 145 (68.7%) had H&amp;N involvement. A significant reduction in EASI H&amp;N scores from baseline to weeks 12\u201316 (38.1%) and week 24 (54.5%) was achieved. Significant improvements in IGA, NRS pruritus, and NRS sleep, and QoL measures emerged within 12\u201316 weeks and persisted at 24 weeks. Compared with patients without H&amp;N involvement, those with H&amp;N involvement exhibited a stronger atopic background and showed no evidence of reduced drug survival. Adverse events, mainly conjunctivitis, were comparable between groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Tralokinumab is effective and well-tolerated in managing moderate-to-severe AD involving the H&amp;N area, even in biologic-experienced patients. These findings support its use as a targeted therapy addressing both clinical and psychosocial burdens of H&amp;N AD.\n                  <\/jats:p>","DOI":"10.1177\/17103568251363249","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T05:02:28Z","timestamp":1758690148000},"page":"982-991","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of Tralokinumab for Moderate-to-Severe Atopic Dermatitis Involving the Head-and-Neck Area: A Multicenter Retrospective Cohort Study"],"prefix":"10.1177","volume":"37","author":[{"given":"Gianluca","family":"Avallone","sequence":"first","affiliation":[{"name":"From the,  Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6479-0986","authenticated-orcid":false,"given":"Luca","family":"Valtellini","sequence":"additional","affiliation":[{"name":"From the,  Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Tavoletti","sequence":"additional","affiliation":[{"name":"From the,  Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7386-3219","authenticated-orcid":false,"given":"Luca","family":"Mastorino","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Maurelli","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia Veronica","family":"Di Brizzi","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ippoliti","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barei","sequence":"additional","affiliation":[{"name":"From the,  Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Termini","sequence":"additional","affiliation":[{"name":"From the,  Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ortoncelli","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Girolomoni","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Balato","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, University of Campania Luigi Vanvitelli, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Gori","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketty","family":"Peris","sequence":"additional","affiliation":[{"name":"Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Valerio","family":"Marzano","sequence":"additional","affiliation":[{"name":"From the,  Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Pathophysiology and Transplantation, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Mariel","family":"Ferrucci","sequence":"additional","affiliation":[{"name":"From the,  Dermatology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2023911"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406223211002979"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.09.035"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2023.2224499"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.058"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000519361"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000590"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.09.028"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14368"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079908x280419"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03426-x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17278"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14264"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad040"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19574"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2153578"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18753"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S382424"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18345"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0138"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.100102.x"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21615"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17744"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-021-01877-8"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.12.1513"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2019.1699516"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-025-00931-1"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14973"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20202"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17981"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20810"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002461"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19108"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.01.012"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17231"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00646-z"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llaf062"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17103568251363249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568251363249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568251363249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:47:03Z","timestamp":1793566023000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17103568251363249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1177\/17103568251363249"],"URL":"https:\/\/doi.org\/10.1177\/17103568251363249","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]}}}