{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:07:40Z","timestamp":1789812460515,"version":"4.0.1"},"reference-count":43,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    The relationship between orofacial granulomatous (OFG) conditions and allergy is evolving. Contact allergies are commonly reported, but the impact of allergy avoidance is unclear, and a current review evaluating this literature has not been performed. We identified 46 studies evaluating the impact of allergen avoidance in OFG (33 case reports, 5 case series, 5 single-arm interventional clinical trials, 1 non-randomized uncontrolled trial, and 2 prospective cohort studies). Patch testing was performed in 158 patients, and the most commonly reported allergens were gold (n = 2), mercury (n = 6), cinnamal\/cinnamon (n = 27), sorbic acid (n = 7), grass\/silver birch\/plant-containing products (n = 22), fragrance (n = 5), nickel (n = 7), and benzoic acid (n = 21). When allergen avoidance was trialed, 123\/171 (71%) of patients reported some degree of improvement. A validated scoring\/grading system for Granulomatous Cheilitis, Melkerrson-Rosenthal syndrome, and OFG has not been developed, so we were unable to formally assess improvement, instead relying on physician- and patient-reported outcomes in addition to oral disease severity score reporting in several studies. Current literature supports both patch testing and a trial of allergen avoidance\/elimination diet to improve OFG in those with a positive result. Few controlled studies have been performed to assess this relationship, and more are needed to evaluate the impact of allergen avoidance. If a patient with difficult-to-treat OFG has a positive patch test and exposure to allergens in their diet, we would recommend a trial of allergen avoidance\/elimination diet to facilitate a multimodal approach to improving control of this difficult condition.\n                  <\/jats:p>","DOI":"10.1177\/17103568251378523","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:17:50Z","timestamp":1758298670000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An Allergy-Based Approach to Orofacial Granulomatosis: A Narrative Review"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-1736","authenticated-orcid":false,"given":"Vikram N.","family":"Sahni","sequence":"first","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Yim","sequence":"additional","affiliation":[{"name":"Tulane University School of Medicine, New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamir","family":"Amanullah","sequence":"additional","affiliation":[{"name":"Temple University School of Medicine, Philadelphia, Pennsylvania, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dev","family":"Sahni","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Powell","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"deShazo","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L.W.","family":"Rhoads","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie T.","family":"Clarke","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Hansen","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Zone","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Hull","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary H.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"From the,  University of Utah Health, Department of Dermatology, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.03.008"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14799"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0488-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.100934"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(85)90038-5"},{"key":"e_1_3_2_7_2","first-page":"32","article-title":"A review of orofacial granulomatosis in a specialist dermatology\/oral medicine clinic","volume":"163","author":"Yesudian PD","year":"2010","unstructured":"Yesudian PD, , Rajlawat BP, , Field EA. 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