{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:26:28Z","timestamp":1793568388444,"version":"4.5.0"},"reference-count":10,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"\n \n \n Abstract:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n \n \n Background:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n Sodium disulfite is a well-established contact allergen. Whether individuals with this contact allergy also experience systemic symptoms after ingesting sulfites remains unclear.\n <\/jats:p>\n \n \n \n Objective:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n To evaluate whether patients with positive patch test reactions to sodium disulfite report systemic symptoms after consuming high-sulfite-containing foods and beverages compared with patch test-negative controls.\n <\/jats:p>\n \n \n \n Methods:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n In this retrospective cross-sectional study, 41 patients with positive and 41 patients with negative patch tests to sodium disulfite completed a standardized survey assessing symptoms (eg, headache, coughing, gastrointestinal distress) following consumption of high-sulfite foods and beverages. Symptom frequency, severity, and triggers were analyzed and compared between groups.\n <\/jats:p>\n \n \n \n Results:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n Systemic symptoms were significantly more common among patch test-positive individuals (57.9%) compared with controls (26.8%,\n P<\/jats:italic>\n = 0.005), particularly with wine (58.1% vs 25.6%,\n P<\/jats:italic>\n = 0.006). Stronger patch test reactions correlated with greater symptom frequency and severity.\n <\/jats:p>\n \n \n \n Conclusions:<\/jats:italic>\n <\/jats:bold>\n <\/jats:underline>\n Patients with sodium disulfite contact allergy more frequently report systemic symptoms after ingesting high-sulfite foods and beverages. These findings suggest a possible overlap between contact allergy and systemic intolerance, supporting a potential role for dietary counseling in select patch test-positive patients.\n <\/jats:p>","DOI":"10.1177\/17103568251386010","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:50:36Z","timestamp":1759481436000},"page":"931-936","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["From Patch to Plate: Evaluation of Systemic Symptoms in Patients With Positive Patch Test Reactions to Sodium Disulfite"],"prefix":"10.1177","volume":"37","author":[{"given":"Sarah","family":"Karels","sequence":"first","affiliation":[{"name":"From the, Department of Dermatology, Park Nicollet Contact Dermatitis Clinic, Park Nicollet, Minneapolis, Minnesota, USA"},{"name":"University of Minnesota Medical School, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brailyn","family":"Weber","sequence":"additional","affiliation":[{"name":"From the, Department of Dermatology, Park Nicollet Contact Dermatitis Clinic, Park Nicollet, Minneapolis, Minnesota, USA"},{"name":"University of North Dakota School of Medicine, Grand Forks, North Dakota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Chrenka","sequence":"additional","affiliation":[{"name":"HealthPartners Institute, Bloomington, Minnesota, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lee","sequence":"additional","affiliation":[{"name":"From the, Department of Dermatology, Park Nicollet Contact Dermatitis Clinic, Park Nicollet, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig","family":"Ophaug","sequence":"additional","affiliation":[{"name":"From the, Department of Dermatology, Park Nicollet Contact Dermatitis Clinic, Park Nicollet, Minneapolis, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0154"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02029.x"},{"issue":"1","key":"e_1_3_1_4_2","first-page":"16","article-title":"Adverse reactions to the sulphite additives","volume":"5","author":"Vally H","year":"2012","unstructured":"Vally H, , Misso NL. Adverse reactions to the sulphite additives. Gastroenterol Hepatol Bed Bench. 2012; 5(1):16\u201323.","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.32473\/edis-fy731-2005"},{"issue":"1","key":"e_1_3_1_6_2","first-page":"3","article-title":"Considerations for the diagnosis and management of sulphite sensitivity","volume":"5","author":"Bold J","year":"2012","unstructured":"Bold J. Considerations for the diagnosis and management of sulphite sensitivity. Gastroenterol Hepatol Bed Bench. 2012; 5(1):3\u20136.","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0420-2"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02135.x"},{"issue":"4","key":"e_1_3_1_9_2","first-page":"139","article-title":"[Diagnostic value of the sulfite skin test]","volume":"26","author":"Gay G","year":"1994","unstructured":"Gay G, , Sabbah A, , Drouet M. [Diagnostic value of the sulfite skin test]. Allerg Immunol (Paris). 1994; 26(4):139\u2013140.","journal-title":"Allerg Immunol (Paris)"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13009"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12440"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17103568251386010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568251386010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568251386010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:47:48Z","timestamp":1793566068000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17103568251386010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1177\/17103568251386010"],"URL":"https:\/\/doi.org\/10.1177\/17103568251386010","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]}}}