{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:46:22Z","timestamp":1792547182508,"version":"4.5.0"},"reference-count":81,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:italic toggle=\"yes\">Abstract:<\/jats:italic>\n                    <\/jats:underline>\n                    Nutritional supplements and topical formulations are increasingly implicated in allergic contact dermatitis (ACD), yet their allergenic potential remains underrecognized due to inconsistent regulatory oversight, limited provider awareness, and the misconception that \u201cnatural\u201d products are inherently safe. To identify emerging allergens in supplements and cosmetics, characterize associated ACD reactions, and highlight diagnostic and regulatory challenges. A systematic review of PubMed, Embase, MEDLINE, Web of Science, and CENTRAL databases was conducted to evaluate reports of ACD linked to dietary supplements and topical formulations. Key sensitizers include vitamin derivatives (\n                    <jats:italic toggle=\"yes\">tocopherol, phytonadione, ascorbic acid<\/jats:italic>\n                    ), herbal extracts (\n                    <jats:italic toggle=\"yes\">Ginkgo biloba, turmeric, St. John\u2019s Wort<\/jats:italic>\n                    ), and antioxidants (\n                    <jats:italic toggle=\"yes\">\u03b1-lipoic acid, resveratrol<\/jats:italic>\n                    ). Documented cases range from localized dermatitis to systemic reactions. Patch testing confirms sensitization, with cross-reactivity and oxidation-related allergenicity frequently observed. Patch testing may not always reveal the sensitizing agent, especially if the allergen is a contaminant, an unlisted ingredient, or undergoes chemical transformation during oxidation or formulation. The rising prevalence of supplement- and cosmetic-induced ACD underscores the need for standardized patch testing, improved ingredient labeling, and enhanced regulatory oversight, including mandated reporting of adverse reactions, premarket safety testing for allergens, and standardized labeling of known sensitizers and botanical components.\n                  <\/jats:p>","DOI":"10.1177\/17103568251387141","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T01:13:51Z","timestamp":1760663631000},"page":"184-194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nutritional Supplements and Cosmetic Formulations: A Review of Emerging Allergens"],"prefix":"10.1177","volume":"37","author":[{"given":"Raymond Z.","family":"Ezzat","sequence":"first","affiliation":[{"name":"From the,  Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Stirrat","sequence":"additional","affiliation":[{"name":"From the,  Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Nichols","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Walter Reed National Military Medical Center\/Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Ehrlich Dermatology, Chevy Chase, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"issue":"61","key":"e_1_3_1_2_2","first-page":"1","article-title":"Dietary supplement use among U.S. adults has increased since NHANES III (1988\u20131994)","author":"Gahche J","year":"2011","unstructured":"Gahche J, , Bailey R, , Burt V, et al. Dietary supplement use among U.S. adults has increased since NHANES III (1988\u20131994). NCHS Data Brief. 2011(61):1\u20138.","journal-title":"NCHS Data Brief"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.117.255984"},{"key":"e_1_3_1_4_2","volume-title":"Allergic Contact Dermatitis","author":"Murphy PB","year":"2024","unstructured":"Murphy PB, , Atwater AR, , Mueller M. Allergic Contact Dermatitis. StatPearls. 2024."},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.766"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2020.10.001"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.1998.11747236"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.118545"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00386.x"},{"issue":"10","key":"e_1_3_1_10_2","first-page":"44","article-title":"Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects","volume":"10","author":"Cohen PR","year":"2017","unstructured":"Cohen PR. Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects. J Clin Aesthet Dermatol. 2017; 10(10):44\u201347.","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12646"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/57.12.1121"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00426.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05809.x"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.147778"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1986.tb03447.x"},{"issue":"11","key":"e_1_3_1_17_2","first-page":"43","article-title":"Curcumin: A contact allergen","volume":"8","author":"Chaudhari SP","year":"2015","unstructured":"Chaudhari SP, , Tam AY, , Barr JA. Curcumin: A contact allergen. J Clin Aesthet Dermatol. 2015; 8(11):43\u201348.","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450508.x"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.116.106468"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/26391.10349"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1351019"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.64719\/pb.4270"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03879.x"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12328"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.15l01790"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000260"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080866"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.07.030"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2014.10.007"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13307"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e318260d7d6"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.09083"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.10018"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01708"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1976.tb03029.x"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00846.x"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1981.tb04113.x"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12460"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(90)90054-3"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1975.tb05443.x"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01264.x"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01388.x"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1989.tb03186.x"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1950.01530120149018"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12115"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1990.tb01514.x"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb00066.x"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.07005"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1985.tb01046.x"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2011.11006"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(98)70379-2"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0107-3"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2020.3786"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb02094.x"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.1139\/o91-010"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.06.017"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1982.tb04214.x"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2020.00045"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14401"},{"key":"e_1_3_1_60_2","volume-title":"A Study of 300 cases of Allergic Contact Dermatitis","author":"Thilak S","year":"2008","unstructured":"Thilak S. A Study of 300 cases of Allergic Contact Dermatitis. Madras Medical College: Chennai; 2008."},{"key":"e_1_3_1_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2004.tb00022.x"},{"key":"e_1_3_1_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14172"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)79763-4"},{"key":"e_1_3_1_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13652"},{"key":"e_1_3_1_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14040"},{"key":"e_1_3_1_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13775"},{"key":"e_1_3_1_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/274156a0"},{"key":"e_1_3_1_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12607"},{"key":"e_1_3_1_69_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00208"},{"key":"e_1_3_1_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14381"},{"key":"e_1_3_1_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.0847c.x"},{"key":"e_1_3_1_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12716"},{"key":"e_1_3_1_73_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12472"},{"key":"e_1_3_1_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12659"},{"key":"e_1_3_1_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13493"},{"key":"e_1_3_1_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12116"},{"key":"e_1_3_1_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1043-4526(01)43005-1"},{"key":"e_1_3_1_78_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2544"},{"key":"e_1_3_1_79_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871530321666201223103411"},{"key":"e_1_3_1_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14362"},{"key":"e_1_3_1_81_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.14170"},{"key":"e_1_3_1_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13128"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17103568251387141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568251387141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568251387141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:58:44Z","timestamp":1781557124000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17103568251387141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,1]]}},"alternative-id":["10.1177\/17103568251387141"],"URL":"https:\/\/doi.org\/10.1177\/17103568251387141","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]}}}