{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:19:12Z","timestamp":1787552352233,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Abstract:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Knowledge about the impact of mild-to-moderate atopic dermatitis (AD) on patients\u2019 physical and mental health in the United States (US) is limited.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    To describe clinical, humanistic, and economic burdens of mild-to-moderate AD in US adults.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Data were analyzed from the 2017 National Health and Wellness Survey (NHWS). NHWS respondents with a self-reported physician\u2019s diagnosis of AD or eczema comprised the AD cohort. Self-reported outcomes assessed included the presence of comorbidities, AD-related sleep disruption severity and impact, anxiety, depression severity, quality of life, mental health, and work and activity impairment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    A total of 4321 respondents in the AD cohort were matched with 4321 respondents in a non-AD control cohort. Comorbidities reported more commonly in the AD versus control cohort included allergies, pain, hypertension, high cholesterol, and food allergies (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05 for all). Self-reported anxiety, sleep difficulties, and depression were more frequent in the AD versus control cohort (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001 for all). Poorer quality of life, worse functional status, and greater impairments to work productivity and daily activity were reported in the AD versus control cohort (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001 for all).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:underline>\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                      <\/jats:bold>\n                    <\/jats:underline>\n                    Mild-to-moderate AD negatively impacts physical, mental, and social domains in adults in the US.\n                  <\/jats:p>","DOI":"10.1177\/17103568261415607","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:29:06Z","timestamp":1771331346000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden of Mild-to-Moderate Atopic Dermatitis in Adults in the United States: Results from the National Health and Wellness Survey"],"prefix":"10.1177","author":[{"given":"Jonathan I.","family":"Silverberg","sequence":"first","affiliation":[{"name":"From the,  The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Smith Begolka","sequence":"additional","affiliation":[{"name":"National Eczema Association, Novato, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelma C.","family":"Chiesa Fuxench","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gruben","sequence":"additional","affiliation":[{"name":"Pfizer Inc., Groton, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela E.","family":"Myers","sequence":"additional","affiliation":[{"name":"Pfizer Inc., Collegeville, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.10.039"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2021.10.002"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000582"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31286-1"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2023911"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3617"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13401"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.07.019"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.08.028"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.07.006"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.08.031"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.325"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2016.1195733"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.04.019"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.10.043"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.1572"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01630-z"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00459-8"},{"issue":"2","key":"e_1_3_1_20_2","first-page":"142","article-title":"Effect of dupilumab on sleep disturbances in adult patients with severe atopic dermatitis","volume":"157","author":"Milanesi N","year":"2022","unstructured":"Milanesi N, , Gola M, , Cartocci A, et al. 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