{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:17:10Z","timestamp":1778145430600,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      The VenaSeal\n                      <jats:sup>\u2122<\/jats:sup>\n                      Closure System uses n-butyl-2-cyanoacrylate for minimally invasive treatment of chronic venous disease. While generally safe, reported adverse events include phlebitis, hypersensitivity, foreign body granulomas, and endovenous glue-induced thrombosis. Specifically, hypersensitivity reactions have been reported in 6.3%\u201313% of patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We present 4 patients with heterogeneous cutaneous and systemic reactions following CAC, ranging from localized nodules to erythroderma. Diagnostic evaluation included patch testing, ultrasound, CT, and histopathology, with varying findings for each case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Consequently, treatments ranged from intralesional corticosteroids to prolonged systemic corticosteroids and surgical excision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case series highlights the limitations of patch testing, the importance of considering imaging and biopsy for diagnosis, and the need for individualized management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17103568261446233","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:31:02Z","timestamp":1777887062000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Spectrum of Hypersensitivity and Granulomatous Reactions to VenaSeal\n                    <sup>\u2122<\/sup>\n                    Cyanoacrylate Closure"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-2384","authenticated-orcid":false,"given":"Mihir M.","family":"Shah","sequence":"first","affiliation":[{"name":"From the \rSchool of Medicine, Stanford University, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Fukaya","sequence":"additional","affiliation":[{"name":"Department of Vascular &amp; Endovascular Surgery, Stanford University, Stanford, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Golara","family":"Honari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer K.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon H.","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Stanford University, Stanford, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_3_1_2_1","unstructured":"1.Medtronic. VenaSealTM closure system. Medtronic. Available from: https:\/\/www.medtronic.com\/en-us\/healthcare-professionals\/products\/cardiovascular\/superficial-vein\/venaseal-closure-system.html [Last accessed: February2 2025]."},{"key":"e_1_3_1_3_1","unstructured":"2.Medtronic. VenaSealTM Procedure\u2014Vein Disease Treatments. Medtronic. Available from: https:\/\/www.medtronic.com\/en-us\/l\/patients\/treatments-therapies\/varicose-vein-treatments\/venaseal-procedure.html [Last accessed: February2 2025]."},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2023.03.018"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0268355519878618"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2023.06.002"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/02683555231211086"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000514"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/derm.2023.0183"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvscit.2020.03.011"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000642"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13206"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006523"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2009.02.019"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.7569\/RAA.2014.097306"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568261446233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17103568261446233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568261446233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:48:33Z","timestamp":1778143713000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17103568261446233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":14,"alternative-id":["10.1177\/17103568261446233"],"URL":"https:\/\/doi.org\/10.1177\/17103568261446233","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"article-number":"17103568261446233"}}