{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:47:35Z","timestamp":1787161655317,"version":"build-2736575974"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Real-world evidence on the long-term use of dupilumab in very young children with moderate-to-severe atopic dermatitis (AD) remains limited. Observational data are needed to complement clinical trial findings by describing treatment outcomes in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multicenter retrospective study included children aged 6 months to 5 years with moderate-to-severe AD treated with dupilumab through the Italian Named Patient Program. Clinical assessments were performed at baseline and at weeks (W) 16, 24, 36, and 52. Disease severity, quality of life, and symptom burden were evaluated using the Eczema Area and Severity Index (EASI), Children\u2019s Dermatology Life Quality Index (c-DLQI), pruritus-numeric rating scale (P-NRS), and sleep-numeric rating scale (S-NRS). EASI-50\/75\/90 responder rates were calculated at each time point. Safety data were collected throughout treatment. Growth parameters were monitored between baseline and W52.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Forty-seven children were included. Dupilumab led to rapid and progressive improvement of AD severity, with mean EASI decreasing from 26.1 at baseline to 2.7 at W52 (\u221289.7%). Marked improvements were also observed in quality of life (\u221291.3% in c-DLQI), itch intensity (\u221282.5% in P-NRS), and sleep disturbance (\u221282.7% in S-NRS). At W52, EASI-75 and EASI-90 responses were achieved by 79.5% and 59.0% of evaluable patients, respectively. Dupilumab was well tolerated, with treatment-emergent adverse events occurring in 10.6% of patients, all mild or moderate and none leading to discontinuation. Weight- and height-for-age\n                      <jats:italic toggle=\"yes\">z<\/jats:italic>\n                      -scores significantly increased over 52 weeks; no child newly developed values below \u22122 standard deviations, although 1 child remained below this threshold at W52. Percentile-based analyses yielded consistent results, confirming the absence of negative effects on growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Dupilumab was effective and well tolerated over 52 weeks in children aged 6 months to 5 years with moderate-to-severe AD, providing sustained skin clearance, symptom relief, and quality-of-life improvement. These findings support dupilumab as a valuable long-term therapeutic option in very young children with uncontrolled AD in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17103568261448380","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:32:26Z","timestamp":1778146346000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Real-Life Effectiveness, Safety, and Growth Outcomes of Dupilumab in Children Aged 6 Months to 5 Years With Moderate-to-Severe Atopic Dermatitis: A Multicenter Retrospective Study from an Italian NPP Program"],"prefix":"10.1177","author":[{"given":"Maddalena","family":"Napolitano","sequence":"first","affiliation":[{"name":"From the \rDepartment of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5607-8877","authenticated-orcid":false,"given":"Giuseppe","family":"Lauletta","sequence":"additional","affiliation":[{"name":"From the \rDepartment of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Turco","sequence":"additional","affiliation":[{"name":"From the \rDepartment of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Boccaletti","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Diluvio","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Dermatology Unit, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, Dermatology Unit, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Tronconi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Unit of Dermatology, Meyer Children\u2019s Hospital, IRCCS, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Giovannini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Unit of Dermatology, Meyer Children\u2019s Hospital, IRCCS, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Ortoncelli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Dermatology Clinic, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Federica","family":"Berti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Section of Dermatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Guerriero","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences of the Abdomen and Metabolism, Unit of Dermatology, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy"},{"name":"Unit of Dermatology, Sacred Heart Catholic University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Omar","family":"Traini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences of the Abdomen and Metabolism, Unit of Dermatology, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy"},{"name":"Unit of Dermatology, Sacred Heart Catholic University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pezzolo","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Hospital San Bortolo, Vicenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elettra","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Medical and Surgical Department, Dermatology Section, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Stingeni","sequence":"additional","affiliation":[{"name":"Medical and Surgical Department, Dermatology Section, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Esposto","sequence":"additional","affiliation":[{"name":"Dermatology Unit, AOU Maggiore della Carit\u00e0, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Mastrorilli","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Emergency, Pediatric Hospital Giovanni XXIII, AOU Policlinic of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Department of Mental and Physical Health and Preventive medicine, Dermatology Unit, Luigi Vanvitelli University of Campania, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Musumeci","sequence":"additional","affiliation":[{"name":"UOC Dermatologia, University of Catania, PO \u201cG. Rodolico\u201d, AOU Policlinico \u201cG. Rodolico-San Marco\u201d, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Azzolini","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology, Central Teaching Hospital Bolzano-Bozen, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zangari","sequence":"additional","affiliation":[{"name":"Clinical and Research Unit of Clinical Immunology and Vaccinology, IRCCS Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Istituto Dermopatico Dell\u2019immacolata IDI-IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Cocuroccia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Istituto Dermopatico Dell\u2019immacolata IDI-IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8413-3186","authenticated-orcid":false,"given":"Iorio","family":"Carmela","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatrics, Castelli Hospital, ASL RM6, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Di Lernia","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sticchi","family":"Alberto","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Grazia","family":"Condorelli","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariavalentina","family":"Catania","sequence":"additional","affiliation":[{"name":"Pediatric Allergology, U.O.C di pediatria ad indirizzo Allergologico e Pneumologico, Arnas Civico Di Cristina Benfratelli di Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics, Federico II University, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cataldo","family":"Patruno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cVincenzo Tiberio\u201d, University of Molise, Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Leuzzi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola Malpighi, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gelmetti","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola Malpighi, Bologna, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iria","family":"Neri","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola Malpighi, Bologna, 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AS Geng B Irvine A et al. Growth analysis in children aged less than 12 years with moderate-to-severe atopic dermatitis. American Academy of Dermatology (AAD) 2024 Annual Meeting: San Diego CA; 2024. Available from: https:\/\/aad-eposters.s3.amazonaws.com\/AM2024\/poster\/51363\/Growth+Analysis+in+Children+Aged+Less+Than+12+Years+with+Moderate-to-Severe+Atopic+Dermatitis.pdf [Last accessed: December16 2024].","DOI":"10.1016\/j.jaad.2024.07.015"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.0627"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-00942-y"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.3696"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-024-01382-y"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad096"},{"key":"e_1_3_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20639"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568261448380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17103568261448380","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17103568261448380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:48:04Z","timestamp":1778312884000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17103568261448380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":22,"alternative-id":["10.1177\/17103568261448380"],"URL":"https:\/\/doi.org\/10.1177\/17103568261448380","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"article-number":"17103568261448380"}}